Results 11 to 20 of about 81,793 (268)

C-reactive protein inhibits survivin expression via Akt/mTOR pathway downregulation by PTEN expression in cardiac myocytes. [PDF]

PLoS ONE, 2014
C-reactive protein (CRP) is one of the most important biomarkers for arteriosclerosis and cardiovascular disease. Recent studies have shown that CRP affects cell cycle and inflammatory process in cardiac myocytes.
Beom Seob Lee, Soo Hyuk Kim, Jaewon Oh, Taewon Jin, Eun Young Choi, Sungha Park, Sang-Hak Lee, Ji Hyung Chung, Seok-Min Kang   +8 more
doaj   +1 more source

Modulations of Cardiac Functions and Pathogenesis by Reactive Oxygen Species and Natural Antioxidants

Antioxidants, 2021
Homeostasis in the level of reactive oxygen species (ROS) in cardiac myocytes plays a critical role in regulating their physiological functions. Disturbance of balance between generation and removal of ROS is a major cause of cardiac myocyte remodeling ...
Sun-Hee Woo, Joon-Chul Kim, Nipa Eslenur, Tran Nguyet Trinh, Long Nguyen Hoàng Do   +4 more
doaj   +1 more source

Calcium Signaling in Cardiac Myocytes [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Calcium (Ca(2+)) is a critical regulator of cardiac myocyte function. Principally, Ca(2+) is the link between the electrical signals that pervade the heart and contraction of the myocytes to propel blood. In addition, Ca(2+) controls numerous other myocyte activities, including gene transcription.
Fearnley, Claire J., Roderick, H. Llewelyn, Bootman, Martin D.   +2 more
openaire   +2 more sources

Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro.

PLoS ONE, 2009
BackgroundMammalian cardiac myocytes withdraw from the cell cycle during post-natal development, resulting in a non-proliferating, fully differentiated adult phenotype that is unable to repair damage to the myocardium, such as occurs following a ...
Carmen H Coxon, Katrina A Bicknell, Fleur L Moseley, Gavin Brooks   +3 more
doaj   +1 more source

Unusual localization and translocation of TRPV4 protein in cultured ventricular myocytes of the neonatal rat

European Journal of Histochemistry, 2012
TRPV4 protein forms a Ca2+-permeable channel that is sensitive to osmotic and mechanical stimuli and responds to warm temperatures, and expresses widely in various kinds of tissues.
Y. Zhao, H. Huang, Y. Jiang, H. Wei, P. Liu, W. Wang, W. Niu   +6 more
doaj   +1 more source

PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.

PLoS ONE, 2010
To identify novel transmembrane and secretory molecules expressed in cardiac myocytes, signal sequence trap screening was performed in rat neonatal cardiac myocytes.
Koji Isodono, Tomosaburo Takahashi, Hiroko Imoto, Naohiko Nakanishi, Takehiro Ogata, Satoshi Asada, Atsuo Adachi, Tomomi Ueyama, Hidemasa Oh, Hiroaki Matsubara   +9 more
doaj   +1 more source

Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice

JACC: Basic to Translational Science, 2016
Cardiac myocytes from the mdx mouse, the mouse model of Duchenne muscular dystrophy, exhibit t-tubule disarray and increased calcium sparks, but a unifying molecular mechanism has not been elucidated.
Kurt W. Prins, MD, PhD, Michelle L. Asp, PhD, Huiliang Zhang, PhD, Wang Wang, MD, PhD, Joseph M. Metzger, PhD   +4 more
doaj   +1 more source

De Novo Human Cardiac Myocytes for Medical Research: Promises and Challenges

Stem Cells International, 2017
The advent of cellular reprogramming technology has revolutionized biomedical research. De novo human cardiac myocytes can now be obtained from direct reprogramming of somatic cells (such as fibroblasts), from induced pluripotent stem cells (iPSCs, which
Veronique Hamel, Kang Cheng, Shudan Liao, Aizhu Lu, Yong Zheng, Yawen Chen, Yucai Xie, Wenbin Liang   +7 more
doaj   +1 more source

Pressure mediated hypertrophy and mechanical stretch up-regulate expression of the long form of leptin receptor (ob-Rb) in rat cardiac myocytes

BMC Cell Biology, 2012
Background Hyperleptinemia is known to participate in cardiac hypertrophy and hypertension, but the relationship between pressure overload and leptin is poorly understood. We therefore examined the expression of leptin (ob) and the leptin receptor (ob-R)
Matsui Hiroki, Yokoyama Tomoyuki, Tanaka Chie, Sunaga Hiroaki, Koitabashi Norimichi, Takizawa Takako, Arai Masashi, Kurabayashi Masahiko   +7 more
doaj   +1 more source

The Hippo pathway regulates density-dependent proliferation of iPSC-derived cardiac myocytes

Scientific Reports, 2021
Inducing cardiac myocytes to proliferate is considered a potential therapy to target heart disease, however, modulating cardiac myocyte proliferation has proven to be a technical challenge.
Abigail C. Neininger, Xiaozhaun Dai, Qi Liu, Dylan T. Burnette   +3 more
doaj   +1 more source