Results 31 to 40 of about 81,793 (268)
Antioxidants, 2021 To investigate the role of NLRP3 inflammasome in cardiac aging, we evaluate here morphological and ultrastructural age-related changes of cardiac muscles fibers in wild-type and NLRP3-knockout mice, as well as studying the beneficial effect of melatonin ...
Ramy K. A. Sayed +9 more
doaj +1 more source
Redox signaling in cardiac myocytes
Free Radical Biology and Medicine, 2011 The heart has complex mechanisms that facilitate the maintenance of an oxygen supply-demand balance necessary for its contractile function in response to physiological fluctuations in workload as well as in response to chronic stresses such as hypoxia, ischemia, and overload.
Xavier Da Costa Dos Santos, Celio Santos +4 more
openaire +3 more sources
Beating the odds: programming proliferation in the mammalian heart
Genome Medicine, 2018 Editorial summary The heart is one of the least regenerative organs in the human body; adult cardiac myocytes divide at extremely low frequency. Therefore, meaningful induction of cardiac regeneration requires in-depth understanding of myocyte cell-cycle
Rajan Jain +2 more
doaj +1 more source
Biomedicines, 2023 Na/K-ATPase (NKA)-mediated regulation of Src kinase, which involves defined amino acid sequences of the NKA α1 polypeptide, has emerged as a novel regulatory mechanism of mitochondrial function in metazoans.
Liquan Cai +7 more
doaj +1 more source
Modeling the isolated cardiac myocyte
Progress in Biophysics and Molecular Biology, 2004 Computer modeling of cardiac myocytes has flourished in recent years. Models have evolved from mathematical descriptions of ionic channels alone to more sophisticated formulations that include calcium transport mechanisms, ATP production and metabolic pathways. The increased complexity is fueled by the new data available in the field.
Jose L, Puglisi +2 more
openaire +2 more sources
Caveolae and the cardiac myocyte [PDF]
Current Opinion in Physiology, 2018 Caveolae, invaginated lipid rafts, orchestrate signalling in the cardiac myocyte. Here we highlight advances in the field which are relevant to the role of caveolae in these cells. Recent analysis of the molecular organisation and structure of the coat complex, which lines the internal surface of caveolae, suggest a stable inner caveolin layer covered ...
Norman, R, Fuller, W, Calaghan, S
openaire +3 more sources
Cardiac Myocyte Exosome Isolation [PDF]
, 2016 Exosomes are cell-derived small extracellular membrane vesicles (50-100 nm in diameter) actively secreted by a number of healthy and diseased cell types. Exosomes can mediate cellular, tissue, and organ level micro communication under normal and pathological conditions by shuttling proteins, mRNA, and microRNAs.
Malik, Zulfiqar A +2 more
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Bioprinting High‐Cell‐Density Cardiac Tissue Constructs With Sustained Contractile Function
Advanced Healthcare Materials, EarlyView.Contractile cardiomyocytes in 3D culture provide insights into the behavior of the heart. Combining a 3D bioprinting approach with a multi‐electrode array allows the development of the 3D culture to be monitored over time, and matured cultures allow the effect of drugs on cardiac function to be modelled, replicating effects seen in clinical application.
Priscila Melo +8 more
wiley +1 more source
Frontiers in Physiology, 2019 Neuregulin (NRG), a paracrine factor in myocytes, promotes cardiac development via the ErbB receptors. NRG-1β also improves cardiac function and cell survival after myocardial infarction (MI), although the mechanisms underlying these cardioprotective ...
Shanell Shoop +11 more
doaj +1 more source