Results 51 to 60 of about 81,793 (268)
A protocol for rapid and parallel isolation of myocytes and non-myocytes from multiple mouse hearts
STAR Protocols, 2021 Summary: This protocol features parallel isolation of myocytes and non-myocytes from murine hearts. It was designed with considerations for (1) time required to extract cardiac cells, (2) cell viability, and (3) protocol scalability.
Gabriella E. Farrugia +9 more
doaj +1 more source
Cell Death in the Cardiac Myocyte
Biological & Pharmaceutical Bulletin, 2015 Loss of cardiac myocytes plays a critical role in the pathogenesis of cardiovascular disorders. A decrease in the number of cardiac myocytes in cardiac diseases results in sustained, irreversible contractile failure of myocardium. Therefore prevention of cardiac cell death is a potential therapeutic strategy for various heart diseases.
Marunouchi, Tetsuro, Tanonaka, Kouichi
openaire +3 more sources
BMEMat, EarlyView.Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang +9 more
wiley +1 more source
Cells, 2017 We previously identified a novel apoptosis-inducing humoral factor in the conditioned medium of hypoxic/reoxygenated-cardiac myocytes. We named this novel post-translationally-modified secreted-form of eukaryotic translation initiation factor 5A ...
Takako Yao +4 more
doaj +1 more source
Communications Biology, 2023 The occurrence of NO/cGMP signalling in cardiac cells is a matter of debate. Recent measurements with a FRET-based cGMP indicator in isolated cardiac cells revealed NO-induced cGMP signals in cardiac fibroblasts while cardiomyocytes were devoid of these ...
Lukas Menges +7 more
doaj +1 more source
From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology
Frontiers in Physiology, 2021 Computational modeling has contributed significantly to present understanding of cardiac electrophysiology including cardiac conduction, excitation-contraction coupling, and the effects and side-effects of drugs.
Karoline Horgmo Jæger +4 more
doaj +1 more source
Intracellular Na+ regulation in cardiac myocytes [PDF]
Cardiovascular Research, 2003 Intracellular [Na+] ([Na+]i) is regulated in cardiac myocytes by a balance of Na+ influx and efflux mechanisms. In the normal cell there is a large steady state electrochemical gradient favoring Na+ influx. This potential energy is used by numerous transport mechanisms, including Na+ channels and transporters which couple Na+ influx to either co- or ...
Donald M, Bers +2 more
openaire +2 more sources
Clinical Anatomy, EarlyView.ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová +11 more
wiley +1 more source
Fueling cardiac myocyte proliferation
The Journal of Cardiovascular Aging[Image: see text]
Manisha Deogharia, Priyatansh Gurha
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Sox6 regulation of cardiac myocyte development [PDF]
Nucleic Acids Research, 2003 A mouse mutation (p100H/p100H) has been identified that is associated with cardioskeletal myopathy, heart block, delayed growth and early postnatal death. The gene that is disrupted in this mutation encodes the transcription factor Sox6. P19CL6 cells were used as an in vitro cardiomyocyte differentiation system and revealed that Sox6 is expressed ...
Orit, Cohen-Barak +5 more
openaire +2 more sources