Results 121 to 130 of about 26,258 (175)

Novel cardiac myosin inhibitor for hypertrophic cardiomyopathy. [PDF]

J Gen Physiol
Szczesna-Cordary D.
europepmc   +1 more source

Bright Ferritin for Non‐Invasive MRI Monitoring of the Fate of Transplanted hPSC‐Cardiomyocytes in the Infarcted Rat Heart

Magnetic Resonance in Medicine, Volume 96, Issue 1, Page 323-338, July 2026.
ABSTRACT Purpose To demonstrate that a recently reported bright ferritin magnetic resonance imaging (MRI) platform can track transplanted human pluripotent stem cell (hPSC)‐derived cardiomyocytes (hPSC‐CMs) longitudinally and on‐demand in the rat heart.
Keyu Zhuang, Faisal J. Alibhai, Beiping Qiang, Rocco Romagnuolo, Kyle D. W. Vollett, Bradley K. C. Freeman, M. Juliana Gomez‐Garcia, Tamilla Sadikov Valdman, Tameshwar Ganesh, Yu‐Qing Zhou, Hai‐Ying Mary Cheng, Michael A. Laflamme, Hai‐Ling Margaret Cheng   +12 more
wiley   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Goal-Directed Versus Self-Directed Valsalva Maneuver in Patients With Hypertrophic Cardiomyopathy on Cardiac Myosin Inhibitor Therapy. [PDF]

JACC Adv
Bavishi A, Soutar M, Kurnides M, Speer H, Oyarce G, Bryde R, Lander B, Richards K, DeMarco K, Martinez MW.   +9 more
europepmc   +1 more source

Circadian‐Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3–NO Pathway

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu, Shiyi Cai, Rong Xie, Chang Liu, Yingzi He   +4 more
wiley   +1 more source

RRAGD p.(Ser76Leu) Variant Causes Dysregulated Expression of Muscle Development and Cytoskeleton Genes in Cardiomyocytes

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Under normal conditions, RagD and mTORC1 respond to amino acid changes. Upon stimulation, active mTORC1 phosphorylates S6K, 4E‐BP1, and TFEB. In response to starvation, mTORC1 is inactive. Our data indicate that the RRAGD p.(Ser76Leu) variant maintains the phosphorylation of mTORC1 targets during starvation in T‐REx HeLa cells.
Anastasia Adella, Sara B. van Katwijk, Pieter A. Leermakers, Willem B. van Ham, Hesther de Ruiter, Judita Ilgutytė, Suzanne Hendrickx, Levi Nijland, Teun P. de Boer, Eva van Rooij, Joost G. J. Hoenderop, Jeroen H. F. de Baaij   +11 more
wiley   +1 more source

Novel Cardiac Myosin Inhibitor Therapy for Hypertrophic Cardiomyopathy in Adults: A Contemporary Review. [PDF]

Am J Cardiovasc Drugs
Kalinski JK, Xu B, Boyd R, Tasseff N, Rutkowski K, Ospina S, Smedira N, Thamilarasan M, Popovic ZB, Desai MY.   +9 more
europepmc   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Multiparametric cardiovascular magnetic resonance evaluation of myocardial perfusion, oxygenation, and energetics in hypertrophic cardiomyopathy following cardiac myosin inhibitor therapy. [PDF]

Eur Heart J Cardiovasc Imaging
Finnigan LEM, Beyhoff N, Ashkir Z, Watkins H, Neubauer S, Raman B.   +5 more
europepmc   +1 more source

Authors' response: septal reduction therapy for obstructive hypertrophic cardiomyopathy. [PDF]

Eur Heart J Open
Schelldorfer A, Kutz A, Yakupoglu HY.
europepmc   +1 more source