Results 121 to 130 of about 2,305,581 (267)

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, Volume 46, Issue 6, Page 1939-1957, November 2026.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Effect of constant-DI pacing on single cell cardiac dynamics

, 2020
University of Minnesota M.S. thesis. 2020. Major: Biomedical Engineering. Advisor: Alena Talkachova. 1 computer file (PDF); 56 pages.Cardiac alternans, beat-to-beat alternations in action potential duration (APD), is a precursor to fatal arrhythmias such
Parthiban, Preethy
core  

Machine Learning‐Based Classification of Right and Left Ventricular Outflow Tract Premature Ventricular Contractions

Annals of Noninvasive Electrocardiology, Volume 31, Issue 6, November 2026.
Machine‐learning analysis of ECG‐derived features and demographic variables enables accurate and interpretable differentiation between RVOT‐ and LVOT‐originating premature ventricular contractions. ABSTRACT Introduction Idiopathic premature ventricular contractions (PVCs) commonly originate from the right and left ventricular outflow tracts (RVOT and ...
Michail Botis, Dimitris Tsiachris, George G. Botis, Aristomenis Koumpanakis, Lamprini Iro Bartsioka, Ioannis Doundoulakis, Athanasios Kordalis, Christos‐Konstantinos Antoniou, Aikaterini‐Eleftheria Karanikola, George K. Matsopoulos, Konstantinos Tsioufis   +10 more
wiley   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Pacing-induced electrophysiological remodeling in hypertrophic obstructive cardiomyopathy--observations on cardiac memory

, 2005
BACKGROUND: Hypertrophic cardiomyopathy carries an increased risk for sudden cardiac death. While pacing therapy reduces the left ventricular outflow tract gradient and improves symptoms in a subgroup of hypertrophic obstructive cardiomyopathy (HOCM ...
Nowinski, K., Linde, C., Gadler, F., Bergfeldt, Lennart,, Wecke, L.   +4 more
core  

Soft Skins With Reversible Thickness Morphing: Materials, Mechanisms, and Applications

Advanced Materials, Volume 38, Issue 55, 1 October 2026.
Evolution of electronic skin (e‐skin) technologies toward adaptive, multifunctional soft skins. Phase I highlights early rigid and discrete sensory interfaces. Phase II shows the transition toward flexible, stretchable, and large‐area e‐skin. Phase III captures the emergence of computational e‐skin.
Oliver Ozioko, Chiamaka Akah, Ravinder Dahiya   +2 more
wiley   +1 more source

Potential and Trend of MXene in Smart Biocomposites Applications: A Review

Advanced Sustainable Systems, Volume 10, Issue 10, October 2026.
MXene‐based biocomposites emerge as a promising class of multifunctional materials that integrate the exceptional electrical, thermal, and electrochemical properties of MXenes with the biocompatibility and sustainability of biopolymers. This review examines their synthesis, fabrication, and structure–property relationships while highlighting ...
Joy Chigozie Anene‐Amaechi, Kehinde James Falua, Amin Babaei‐Ghazvini, Bishnu Acharya   +3 more
wiley   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, Volume 13, Issue 59, 23 October 2026.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Left bundle branch area pacing induced dual bundle branches non-reentrant bigeminy and Takotsubo cardiomyopathy: a case report. [PDF]

Front Physiol
Chu SY, Li Y, Qi LT, Chen ED, Zhou J.
europepmc   +1 more source