Results 91 to 100 of about 1,622,247 (397)

Fatal heart block from intentional yew tree (Taxus baccata) ingestion: a case report [PDF]

, 2019
© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org ...
Chan, Mark, G, Natasha, Gorog, Diana, Gue, Ying X.   +3 more
core   +2 more sources

Repurposing With Purpose: Treatment of Bachmann–Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp, Elizabeth A. VanSickle, Julianne Michael, Chad R. Schultz, Kelly Nguyen, Melissa Hoefer, Surender Rajasekaran, André S. Bachmann   +7 more
wiley   +1 more source

DNA methylation-based telomere length is more strongly associated with cardiovascular disease and long-term mortality than quantitative polymerase chain reaction-based telomere length: evidence from the NHANES 1999–2002

Clinical Epigenetics
Background Telomere length (TL) serves as a pivotal gauge of cellular aging, with shorter TL linked to various age-related ailments. Recently, a DNA methylation-based TL estimator, known as DNAmTL, has emerged as a novel TL measurement tool.
Qianhui Wang, Yuanfeng Gao, Jie Song, Dilare Taiwaikuli, Huanhuan Ding, Xinchun Yang, Baopeng Tang, Xianhui Zhou   +7 more
doaj   +1 more source

Cardiac parasympathetic modulation in the setting of radiofrequency ablation for atrial fibrillation

Archives of Medical Science, 2019
The cardiac autonomic nervous system plays an important role in the genesis and maintenance of atrial fibrillation. Although, pulmonary vein isolation is the cornerstone in today’s approach to atrial fibrillation ablation, a considerable proportion of ...
Thiago G. Osório, Gaetano Paparella, Sebastian Stec, Gian Battista Chierchia, Carlo de Asmundis   +4 more
doaj   +1 more source

Bioprinting‐Assisted Tissue Assembly to Investigate Endothelial Cell Contributions in Cardiac Fibrosis and Focal Fibrosis Modeling

Advanced NanoBiomed Research, EarlyView.
GA: Bioprinting‐assisted tissue assembly, a method for generating versatile and complex tissue constructs, is employed to investigate the contribution of endothelial cells (ECs) in cardiac fibrosis. ECs modulate fibrotic responses not only by preventing significant tissue stiffening and contractile impairment but also by exhibiting endothelial‐to ...
Dong Gyu Hwang, Hwanyong Choi, Myungji Kim, Minji Kim, Donghwan Kim, Jinseon Park, Jinah Jang   +6 more
wiley   +1 more source

Cryothermal Energy Ablation Of Cardiac Arrhythmias 2005: State Of The Art [PDF]

, 2005
At the time of antiarrhythmic surgery, cryothermal energy application by a hand-held probe was used to complement dissections and resections and permanently abolish the arrhythmogenic substrate.
De Ponti, Roberto
core   +2 more sources

Effects of early afterdepolarizations on excitation patterns in an accurate model of the human ventricles [PDF]

, 2017
Early Afterdepolarizations, EADs, are defined as the reversal of the action potential before completion of the repolarization phase, which can result in ectopic beats.
Panfilov, Alexander, Seemann, Gunnar, Van Nieuwenhuyse, Enid, Vandersickel, Nele   +3 more
core   +3 more sources

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Accepted Article.
Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Rate-dependent propagation of cardiac action potentials in a one-dimensional fiber

, 2004
Action potential duration (APD) restitution, which relates APD to the preceding diastolic interval (DI), is a useful tool for predicting the onset of abnormal cardiac rhythms.
C. L. Gibbs, D. R. Chialvo, Daniel J. Gauthier, David G. Schaeffer, Elena G. Tolkacheva, J. D. Murray, John W. Cain, L. S. Gettes, M. R. Boyett, M. R. Guevara, M. Watanabe, V. Elharrar   +11 more
core   +1 more source

Gamifying anatomy outreach: An underexplored opportunity

Anatomical Sciences Education, EarlyView.
Abstract This article explores the underutilized potential of incorporating gamified approaches into anatomy outreach initiatives. While gamification and game‐based learning approaches have been widely adopted in formal educational settings, there is a surprising lack of research on their application for community‐based public engagement with anatomy ...
Mikaela L. Stiver, Aamna Naveed, John Chilton, Siobhan M. Moyes   +3 more
wiley   +1 more source