Results 61 to 70 of about 100,983 (296)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Mechanisms of Vein of Marshall-Related Tachyarrhythmias and the Impact of Ethanol Infusion

Reviews in Cardiovascular Medicine
The Ligament of Marshall (LOM) is a remnant of the embryonic sinus venosus and the left cardinal vein, containing a combination of fat, fibrous tissue, blood vessels, muscle bundles, nerve fibers, and ganglia.
Masateru Takigawa, Claire Martin, Pierre Jaïs   +2 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]

, 2005
Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Biliczki, Péter, Bitay, Miklós, Bogáts, Gábor, Jost, Norbert, Lathrop, David A., Lengyel, Csaba Attila, Nagy, Zsolt, Papp, Gyula, Takács, János, Varró, András, Virág, László   +10 more
core   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Acute and one year outcome of premature ventricular contraction ablation guided by contact force and automated pacemapping software

Journal of Arrhythmia, 2019
Background Radiofrequency (RF) ablation is a well‐established approach to treat premature ventricular contractions (PVC) and is associated with good outcomes.
Lucio Capulzini, Pasquale Vergara, Giacomo Mugnai, Francesca Salghetti, Juan Pablo Abugattas, Said El Bouchaibi, Saverio Iacopino, Juan Sieira, Hugo Enriquez Coutiño, Erwin Ströker, Pedro Brugada, Gianbattista Chierchia, Carlo deAsmundis   +12 more
doaj   +1 more source

Impact of a Right Ventricular Impedance Sensor on the Cardiovascular Responses to Exercise in Pacemaker Dependent Patients [PDF]

, 2005
Background. The evaluation of the heart rate (HR) response to exercise is important for the assessment of the rate response algorithm of sensor-controlled pacemakers.
Corey, Tomczak, Edward, Busse, John, Tsang, Linnea, Cook, Robert, Haennel, Tada, Hiroshi, Wladyslaw, Wojcik   +6 more
core  

Smart Optogenetics for Real‐Time Automated Control of Cardiac Electrical Activity

Advanced Science, EarlyView.
We are able to stop dangerous heart‐rhythm spirals before they fully form. Within about 100 ms, it pinpoints the spiral's tiny central tip (≈0.9 mm) using light‐based sensing and machine learning, then shines targeted light to shut it down. This fast, precise, closed‐loop approach detects, targets, and terminates arrhythmias in real time.
Shanliang Deng, Niels Harlaar, Juan Zhang, Sven O. Dekker, Nina N. Kudryashova, Huiling Zhou, Cindy I. Bart, TianYi Jin, Georgy Derevyanko, Willem van Driel, Alexander V. Panfilov, René H. Poelma, Antoine A. F. de Vries, GuoQi Zhang, Tim De Coster, Daniël A. Pijnappels   +15 more
wiley   +1 more source

Transesophageal Electrophysiological Study in Management of Pediatric tachyarrhythmias

Indian Pacing and Electrophysiology Journal, 2022
A. Manickavasagam, S.C.S. Patloori, H.T. Perla, D. Chase, J. Roshan   +4 more
doaj   +1 more source

Increased baseline ECG R-R dispersion predicts improvement in systolic function after atrial fibrillation ablation. [PDF]

, 2019
BackgroundAtrial fibrillation (AF) is associated with left ventricular (LV) systolic dysfunction which may improve after AF ablation. We hypothesised that increased ventricular irregularity, as measured by R-R dispersion on the baseline ECG, would ...
Buch, Eric, Chandrashekhar, Y, Koene, Ryan J, Li, Jian-Ming, Mbai, Mackenzi, Seo, Young-Ji, Shivkumar, Kalyanam, Tholakanahalli, Venkatakrishna N   +7 more
core   +1 more source