Results 81 to 90 of about 1,580,434 (356)

Repurposing With Purpose: Treatment of Bachmann–Bupp Syndrome With Eflornithine and Implications for Other Polyaminopathies

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost of drug development that is not proportionate to the number of patients who
Caleb P. Bupp   +7 more
wiley   +1 more source

Bioprinting‐Assisted Tissue Assembly to Investigate Endothelial Cell Contributions in Cardiac Fibrosis and Focal Fibrosis Modeling

open access: yesAdvanced NanoBiomed Research, EarlyView.
GA: Bioprinting‐assisted tissue assembly, a method for generating versatile and complex tissue constructs, is employed to investigate the contribution of endothelial cells (ECs) in cardiac fibrosis. ECs modulate fibrotic responses not only by preventing significant tissue stiffening and contractile impairment but also by exhibiting endothelial‐to ...
Dong Gyu Hwang   +6 more
wiley   +1 more source

Young patient with curious preexcitation: Ready to fly before catheters placement

open access: yesIndian Pacing and Electrophysiology Journal, 2021
Javier Ramos Jiménez   +3 more
doaj   +1 more source

DNA methylation-based telomere length is more strongly associated with long-term all-cause mortality than quantitative polymerase chain reaction-based telomere length among middle-aged and older hypertensive adults

open access: yesClinical Epigenetics
Background Telomere length (TL) has been linked to mortality risk across various populations. However, its predictive value for mortality risk specifically in hypertensive adults remains unclear. Methods This cohort study utilized data from the 1999–2000
Qianhui Wang   +7 more
doaj   +1 more source

Randomized Trial of Left Bundle Branch vs Biventricular Pacing for Cardiac Resynchronization Therapy.

open access: yesJournal of the American College of Cardiology, 2022
Yao Wang   +20 more
semanticscholar   +1 more source

B cells and systemic sclerosis interstitial lung disease

open access: yesArthritis &Rheumatology, Accepted Article.
Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman   +2 more
wiley   +1 more source

Retrieval of fragmented coronary sinus catheter in the right atrium: A first novel multidisciplinary approach in sub-Saharan Africa

open access: yesHeart Rhythm O2, 2023
Yona Gandye, MD, MMed, MSc   +5 more
doaj   +1 more source

ELECTROPHYSIOLOGY: Temporary cardiac pacing [PDF]

open access: yesHeart, 2000
Paul Zoll first applied clinically effective temporary cardiac pacing in 1952 using a pulsating current applied through two electrodes attached via hypodermic needles to the chest wall in two patients with ventricular standstill.1 Although this technique was uncomfortable for the patients it was effective for 25 minutes in one patient and nearly five ...
openaire   +3 more sources

Gamifying anatomy outreach: An underexplored opportunity

open access: yesAnatomical Sciences Education, EarlyView.
Abstract This article explores the underutilized potential of incorporating gamified approaches into anatomy outreach initiatives. While gamification and game‐based learning approaches have been widely adopted in formal educational settings, there is a surprising lack of research on their application for community‐based public engagement with anatomy ...
Mikaela L. Stiver   +3 more
wiley   +1 more source

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