Results 81 to 90 of about 8,969 (219)

Divergent exploratory‐avoidant behavioural strategies may drive niche differentiation in juvenile Antarctic fishes

Journal of Fish Biology, EarlyView.
Abstract We used an ecological niche theory framework integrating physiological and behavioural ecology to understand interspecific differentiation of juveniles of four Antarctic fishes: Trematomus bernacchii, Trematomus pennellii, Trematomus nicolai and Pagothenia borchgrevinki.
Amanda J. Frazier, Andrew W. Naslund, Milica Mandic, Kenneth W. Zillig, Bryant C. Siu, Anne E. Todgham   +5 more
wiley   +1 more source

Navigating the Zero Fluoroscopy Frontier: Current Tools, Evidence and Future Directions in Electrophysiology Procedures

Pacing and Clinical Electrophysiology, EarlyView.
Graphical Abstract ABSTRACT Fluoroscopy has traditionally been the mainstay imaging technique for guidance during electrophysiology (EP) ablation procedures. The numerous disadvantages associated with radiation exposure for both operators and patients have created the need for zero‐fluoroscopy (ZF) approaches. Today, electrophysiologists have access to
Dimitrios Kotzadamis, Georgios Giannopoulos, Vaios Schismenos, Alexandros Evangeliou, Prokopios Mamolis, Antonios Antoniadis, Vassilios Vassilikos   +6 more
wiley   +1 more source

Diagnostic Accuracy of 12‐Lead ECG Algorithms for Accessory Pathway Localization in WPW: A Meta‐Analysis

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background In Wolff–Parkinson–White (WPW) syndrome, accurate localization of accessory pathways before catheter ablation can improve procedural planning and efficiency. Several 12‐lead electrocardiographic (ECG) algorithms have been proposed, but their diagnostic performance has not been consistently established.
Elsayed S. Moubarak, Ahmed Farid Gadelmawla, Almothana Manasrah, Anas Mansour, Mohamed S. Elgendy, Omar Elkoumi, Husam Abu Suilik, Suhaib El Khatib, Naser Albekaen, Ahmed Moustafa, Rania Samir, Islam Saboukh, Nadica Trajkovska, Angeliki Darma, Vanessa Sciacca, Thomas Fink, Moneeb Khalaph, Christian Sohns, Philipp Sommer, Hassan El‐Shirbiny   +19 more
wiley   +1 more source

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Advanced imaging and multi‐omics to characterize cardiomyocyte ageing and its electrocardiographic imprint in PKP2 arrhythmogenic cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend We used a murine model of cardiomyocyte‐specific conditional knockout of plakophilin 2 (PKP2cKO, middle panel). Using advanced imaging technology, we unveiled distinct hallmarks of premature ageing in PKP2cKO cardiomyocytes, including DNA damage and loss of repressed heterochromatin at the nuclear periphery, and mitochondrial ...
Giorgia Bertoli, Kavya Phadke, Alessandro Cospito, Xianming Lin, Marina Cerrone, Joanna Abi Rizk, Michael Cammer, Yan Deng, Joseph Sall, Mingliang Zhang, Feng‐Xia Liang, Irene de Lázaro, Mario Delmar   +12 more
wiley   +1 more source

Kinematic‐calcium loops unravel impaired excitation–contraction coupling in MELAS‐affected cardioids

The Journal of Physiology, EarlyView.
Abstract figure legend Representation of kinematic and calcium transient loop with respect to traditional time coplotting. Abstract Impaired Ca2+ handling, and in particular leakage from the sarcoplasmic reticulum, is a critical mechanism in metabolic diseases affecting the heart.
Margherita Burattini, Annalinda Pisano, Maria Gemma Pignataro, Giulia d'Amati, Silvana Pinelli, Minh Long Hoang, Francesco Paolo Lo Muzio, Michele Miragoli   +7 more
wiley   +1 more source

Dyssynchrony without dysfunction: Left bundle branch block does not acutely reduce cardiac output

The Journal of Physiology, EarlyView.
Abstract figure legend Six electromechanical in silico heart models were simulated under healthy and pure acute left bundle branch block (LBBB) conditions. LBBB induced electrical dyssynchrony and increased left ventricular free wall strain, while the right and left ventricular ejection fraction remained relatively unchanged.
Carola Kruthoff, Jonathan Krauß, Jorge Sánchez, Tobias Gerach, Cristian Barrios Espinosa, Jan‐Erik Duhme, Axel Loewe   +6 more
wiley   +1 more source

Slow calcium removal contributes to impaired lusitropic response to β‐adrenergic stimulation in HFpEF mice

The Journal of Physiology, EarlyView.
Abstract figure legend Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart failure, yet major gaps remain in our understanding of its underlying mechanisms, disease progression and effective treatment strategies. Mice with HFpEF exhibited exercise intolerance and diastolic dysfunction in vivo, while isolated hearts ...
Tamzin Zawadzki, Diana S. Usai, Sif G. Kaad, Katrine H. Rasmussen, Mie S. Larsen, Jens C. B. Jacobsen, Morten B. Thomsen   +6 more
wiley   +1 more source