Results 121 to 130 of about 1,539,414 (291)

Cardiac Stimulation Through Induced Currents

, 2017
This paper presents the magnetic cardiac stimulation, more precisely the stimulation with an electric field produced by a time-variable magnetic field. The modeling within this domain has in view the investigation of the induced currents in the body and ...
Oana Drosu, Marilena Stanculescu
core   +1 more source

Renal denervation: back on track

Kidney Research and Clinical Practice, 2018
Márcio Galindo Kiuchi
doaj   +1 more source

Characterization, number, and spatial organization of nerve fibers in the human cervical vagus nerve and its superior cardiac branch

Brain Stimulation
Background: Electrical stimulation of the vagus nerve (VN) is a therapy for epilepsy, obesity, depression, and heart diseases. However, whole nerve stimulation leads to side effects.
Bettina Kronsteiner, Genova Carrero-Rojas, Lukas F. Reissig, Atieh Seyedian Moghaddam, Karoline M. Schwendt, Sylvia Gerges, Udo Maierhofer, Oskar C. Aszmann, Angel M. Pastor, Attila Kiss, Bruno K. Podesser, Wolfgang Birkfellner, Francesco Moscato, Roland Blumer, Wolfgang J. Weninger   +14 more
doaj   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Atrial fibrillation and chronic kidney disease: A bad combination

Kidney Research and Clinical Practice, 2018
Márcio Galindo Kiuchi
doaj   +1 more source

Influence of cardiac phases on cortico-spinal excitability: Insights from input-output curves

NeuroImage
Visceral signals, such as cardiac oscillations, are considered a significant source influencing ongoing cortical activity. Research has shown that perceptual and cognitive functions fluctuate with the heart cycle.
Paolo Di Luzio, Mauro Gianni Perrucci, Francesca Ferri, Marcello Costantini   +3 more
doaj   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

The effect of glucose on cardiac AMP-activated protein kinase [PDF]

, 2009
AMP-activated protein kinase (AMPK) serves as an energy-sensing protein that is activated by a variety of metabolic stresses. Recent studies suggest that AMPK is also regulated by hormones and by nutrients such as glucose and fatty acids.
Tabidi, I.
core