Results 191 to 200 of about 4,426,309 (413)
Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis
Advanced Science, EarlyView.Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.Jiayu Guo, Yan Wang, Qiudi Liu, Zhaoyang Luo, Xiaomu Tian, Yuquan Wang, Yang Liu, Zhiwei Ning, Yingying Guo, Huiying Gao, Xinyue Wang, Jinglong Feng, Mengmeng Liu, Dina Saifullina, Yixin Zhang, Tengfei Pan, Yu Bian, Tao Ban, Tianyu Li, Yunyan Gu, Haihai Liang +20 morewiley +1 more sourceRestrictive or Liberal Red‐Cell Transfusion for Cardiac Surgery
New England Journal of Medicine, 2017 D. Mazer, R. Whitlock, D. Fergusson, Judith Hall, E. Belley‐Cote, K. Connolly, Boris Khanykin, A. Gregory, É. de Médicis, S. McGuinness, A. Royse, F. Carrier, P. Young, J. Villar, H. Grocott, M. Seeberger, S. Fremes, F. Lellouche, S. Syed, K. Byrne, S. Bagshaw, N. Hwang, C. Mehta, T. Painter, C. Royse, S. Verma, G. Hare, A. Cohen, K. Thorpe, P. Jüni, N. Shehata +30 moresemanticscholar +1 more sourceHistone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules
Advanced Science, EarlyView.These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.Xikai Liu, Xinran Liu, Mei Xue, Yushuo Xiao, Yuchen Chen, Rong Qiu, Di Wu, Yihao Zhou, Jiao Wang, Yan Yuan, Linwei Yu, Tianyi Shi, Yangkai Li, Hua Su, Hong Chen, Yong Liu, Kun Huang, Ling Zheng +17 morewiley +1 more sourceLeptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells
Advanced Science, EarlyView.Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen +18 morewiley +1 more source