Results 171 to 180 of about 273,643 (353)

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF‐β1/Smads and Activating Nrf2‐ARE Signaling in MI Rodent

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF‐
Jiunn‐Jye Sheu   +6 more
wiley   +1 more source

The influence of a half-marathon upon cardiac troponin T release in adolescent runners

open access: yes, 2011
Objectives: Post-exercise cardiac troponin T (cTnT) release has been widely reported in adult athletes but limited data is available for adolescents. The aim of this study was to determine the incidence and magnitude of cTnT appearance in a large group ...
Tong, T.K.   +6 more
core   +1 more source

Vaccarin Improves Myocardial Ischemia–Reperfusion Injury by Attenuating Oxidative Stress and Ferroptosis Through Reducing NOX4‐Modulated JAK2/STAT3 Pathway Activation

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Vaccarin is a naturally occurring flavonoid glycoside with cardioprotective properties; however, its involvement in myocardial ischemia–reperfusion (MI/R) injury remains poorly defined. We herein investigated whether vaccarin protects cardiomyocytes from MI/R‐induced dysfunction in vivo and in vitro and examined the associated molecular ...
Han Yang, Mi Zhou, Feng‐Cai Zhang
wiley   +1 more source

Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao   +6 more
wiley   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction

open access: yesClinics, 2013
OBJECTIVE: Recent studies have shown that circulating microRNAs might be useful, novel biomarkers for the diagnosis of acute myocardial infarction. The aims of this study were to evaluate the expression of cardiac-specific miRNAs (miR-1, -133a, -208b ...
Ying-Qing Li   +9 more
doaj  

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)

open access: yesPhytotherapy Research, EarlyView.
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo   +11 more
wiley   +1 more source

Origin of Cardiac Troponin T Elevations in Chronic Kidney Disease.

open access: yesCirculation, 2017
N. van der Linden   +15 more
semanticscholar   +1 more source

SAFE: a Mix‐and‐Read Assay for miRNA Detection in Extracellular Vesicles From Unprocessed Plasma Toward Clinical Disease Diagnosis

open access: yesSmall, EarlyView.
SAFE (Sonication‐Assisted liposome Fusion with EVs) is a rapid, mix‐and‐read assay that directly detects extracellular vesicle–encapsulated miRNAs from unprocessed plasma. By delivering molecular beacons into EVs via sonication‐driven liposome fusion, the method enables intravesicular hybridization with minimal background, providing quantitative ...
Subhra Sulipta Jena   +9 more
wiley   +1 more source

Thrombin-Mediated Degradation of Human Cardiac Troponin T.

open access: yesClinical Chemistry, 2017
I. Katrukha   +6 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy