Results 51 to 60 of about 2,380 (223)
Some models produced by 3D iterations (Infinite Combinatorics and Forcing Theory) [PDF]
, 2017 We use the techniques in [BFII, Mej13b, FFMM] to construct models, by threedimensional arrays of ccc posets, where many classical cardinal characteristics of the continuum are pairwise ...
Mejía, Diego Alejandro
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Continuum Many Different Things: Localisation, Anti-Localisation and Yorioka Ideals
Combining creature forcing approaches from arXiv:1003.3425 and arXiv:1402.0367, we show that, under CH, there is a proper $\omega^\omega$-bounding poset with $\aleph_2$-cc that forces continuum many pairwise different cardinal characteristics ...
Cardona, Miguel Antonio +2 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Crowded and Selective Ultrafilters under the Covering Property Axiom
, 2003 In the paper we formulate an axiom CPA_{prism}^{game}, which is the most prominent version of the Covering Property Axiom CPA, and discuss several of its implications.
Ciesielski, Krzysztof
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Small Combinatorial Cardinal Characteristics and Theorems of Egorov and Blumberg
, 2000 We will show that the following set theoretical assumption \continuum=\omega2, the dominating number d equals to \omega1, and there exists an \omega1-generated Ramsey ultrafilter on \omega (which is consistent with ZFC) implies that for an arbitrary ...
Ciesielski, Krzysztof
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source