Results 81 to 90 of about 1,736,765 (225)

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Organoprotective effects of serelaxin in patients with severe decompensated heart failure

Рациональная фармакотерапия в кардиологии, 2016
Serelaxin (recombinant molecule of the human relaxin-2) is an innovative drug for the treatment of acute heart failure. Preclinical and clinical studies demonstrated the ability of serelaxin to relieve the symptoms of heart failure, provide a significant
Z. D. Kobalava, S. V. Villevalde, A. E. Solov'jova, I. A. Merai   +3 more
doaj   +1 more source

Spontaneous Chylothorax in a Case of Cardio-Facio-Cutaneous Syndrome

, 2009
A patient is reported who fulfills the diagnostic criteria for severe cardio-facio-cutaneous syndrome who developed a chylothorax.
CHAN, PEI-CHUN;CHIU, HSIEN-CHING;HWU, WUH-LIANG, 詹珮君;邱顯清;胡務亮   +1 more
core  

Menopause and vascular endothelial health: Is it all about the oestrogen?

Experimental Physiology, EarlyView.
Abstract Cardiovascular disease (CVD) is a leading cause of mortality in women, and CVD risk is accelerated during the menopause transition. This acceleration has traditionally been attributed to the hallmark decline in oestradiol with menopause. However, the menopause transition is also characterized by changes in other sex hormones that exert effects
Virginia R. Nuckols, Allyson I. Schwab, Lyndsey E. DuBose, Kerrie L. Moreau, Megan M. Wenner   +4 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Cardio-renal-metabolic syndrome – an independent clinical picture?

Cardiologia Hungarica
Chronic kidney disease (CKD) and heart diseases (cardiovascular disease, atherosclerotic heart disease, heart failure) and metabolic diseases (metabolic syndrome [MetS], type 2 diabetes [T2DM], hyperuricemia) often occur together.
Ede Kékes
doaj   +1 more source

Role of hypoxia inducible factor pathway in cardiorenal syndrome and application prospect of HIF stabilizer

Linchuang shenzangbing zazhi, 2022
Cardiorenal syndrome （CRS） involves multiple organs. It refers to acute or chronic cardiac or renal dysfunction. Its pathophysiology involves immune inflammation，oxidative damage，anemia，iron metabolism disorders，dyslipidemia，hemodynamic disorders ...
A Rou-na, He Fang-fang, Sun Xin, Luo Chang-qing   +3 more
doaj  

Lung‐Cardiovascular Interactions and Derangements in ARDS

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
This review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.
Pablo A. Sanchez, Connor O'Brien, Matthieu Legrand, Carolyn S. Calfee, Michael A. Matthay   +4 more
wiley   +1 more source

A Geospatial Linkage Analysis of Environmental Exposures, Socioeconomic Profile and Health Outcomes Among Women of Reproductive Age in Victoria, Australia

Health Promotion Journal of Australia, Volume 37, Issue 4, October 2026.
ABSTRACT Issue Addressed Non‐communicable disorders (NCDs) in women of reproductive age (WRA) shape maternal and intergenerational outcomes, yet their area‐level socio‐environmental drivers remain unclear. We examined correlations between socio‐environmental factors and NCDs in WRA.
Catherine Helenna Mulyadi, Lisa Hui, Heng Jiang, Mari de Leon, J. C. Nacpil, Yichao Wang, Jason Choi, Suzanne Mavoa, Melvin Barrientos Marzan   +8 more
wiley   +1 more source

A new insight into the treatment of renal anemia with HIF stabilizer

Renal Replacement Therapy, 2020
The long-term clinical experiences with recombinant human erythropoietin (rHuEPO) and its analog derivatives have clearly proven that correction of anemia with erythropoiesis stimulating agent (ESA) not only reduces blood transfusion and improves ...
Satoru Kuriyama, Yukio Maruyama, Hirokazu Honda   +2 more
doaj   +1 more source