Results 71 to 80 of about 39,995 (259)

A Cytoplasmic pH Sensor Redefines Gating in Bacterial Urea Channels and Acid Resistance

Small, EarlyView.
Bacterial survival in acidic environments requires pH‐gated urea channels. Utilizing complementary approaches, we identify a conserved cytoplasmic glutamic acid residue as a pH sensor in UreI channels. Whereas Gram‐positive bacteria rely solely on this sensor, Gram‐negative bacteria employ a dual‐sensor mechanism with periplasmic residues, revealing a ...
Anna Stoib, Sahar Shojaei, Xenia Fischer, Sandra Posch, Gianluca Parisse, Mario Frezzini, Tobias Putz, Christine Siligan, Nikolaus Goessweiner‐Mohr, Daniele Narzi, Andreas Horner   +10 more
wiley   +1 more source

Lipid Coating Modulates Effects of Nanoceria on Oxidative Metabolism in Human Embryonic Lung Fibroblasts: A Case of Cardiolipin

Biomolecules
The unique redox properties of nanoscale cerium dioxide determine its diverse application in biology and medicine as a regulator of oxidative metabolism. Lipid modifiers of the nanoparticle surface change their biochemical properties and bioavailability.
Elena V. Proskurnina, Madina M. Sozarukova, Elizaveta S. Ershova, Ekaterina A. Savinova, Larisa V. Kameneva, Natalia N. Veiko, Maria A. Teplonogova, Vladimir P. Saprykin, Vladimir K. Ivanov, Svetlana V. Kostyuk   +9 more
doaj   +1 more source

Selective remodeling of cardiolipin fatty acids in the aged rat heart

Lipids in Health and Disease, 2006
Background The heart is rich in cardiolipin, a phospholipid acylated in four sites, predominately with linoleic acid. Whether or not aging alters the composition of cardiolipin acyl chains is controversial.
Rapoport Stanley I, Mayette Jana, Lee Ho-Joo, Bazinet Richard P   +3 more
doaj   +1 more source

Structure of an Inner Membrane Protein Required for PhoPQ-Regulated Increases in Outer Membrane Cardiolipin

mBio, 2020
The Salmonella enterica subsp. enterica serovar Typhimurium PhoPQ two-component system is activated within the intracellular phagosome environment, where it promotes remodeling of the outer membrane and resistance to innate immune antimicrobial peptides.
Junping Fan, Erik M. Petersen, Thomas R. Hinds, Ning Zheng, Samuel I. Miller   +4 more
doaj   +1 more source

The role of cardiolipin in mitochondrial function and apoptosis

, 2015
The phospholipid cardiolipin is thought to play an important role in mitochondrial physiology and mitochondrial outer membrane permeabilization (MOMP) during apoptosis. However, this remains controversial due to the lack of good cellular models.
Raemy, Etienne
core   +1 more source

Cardiolipin-Mediated Alleviation of Mitochondrial Dysfunction Is a Neuroprotective Effect of Statin in Animal Model of Ischemic Stroke

, 2023
In clinical settings, the benefit of statin for stroke is debatable as regular statin users may suffer from myalgia, statin-associated myopathy (SAM), and rarely rhabdomyolysis.
Swapnil Raut, Abhishek Sarkar, Bijoyani Ghosh (14516139), Pallab Bhattacharya (453692), Nikita Rana (14516142), Vrushali Thongire, Anupom Borah, Deepaneeta Sarmah (6898931), Swapnil Raut (14516157), Deepaneeta Sarmah, Pallab Bhattacharya, Aishika Datta (11462010), Bijoyani Ghosh, Namrata Vadak, Aishika Datta, Upasna Singh (14516160), Namrata Vadak (14516154), Antra Chaudhary, Shubhrakanta Sahu, Upasna Singh, Vishal Gupta, Shubhrakanta Sahu (14516145), Vishal Gupta (763297), Abhishek Sarkar (2941962), Anupom Borah (3723307), Nikita Rana, Harpreet Kaur, Harpreet Kaur (107427), Vrushali Thongire (14516148), Antra Chaudhary (14516151)   +29 more
core   +1 more source

CryoBN‐PAGE: A Rapid and Cost‐Effective Method for the Analysis of Yeast Respiratory Complexes and Their Dynamic Organization

Yeast, EarlyView.
We present cryoBN‐PAGE, a method that enables blue native polyacrylamide gel electrophoresis analysis of mitochondrial respiratory complexes and supercomplexes directly from whole yeast cells using cryogenic milling. This approach eliminates the need for mitochondrial isolation, reducing time and cost while preserving native protein complexes.
Lizeth J. Camacho Lopez, Mazzen H. Eldeeb, Elliana G. Mohrhardt, Flavia Fontanesi   +3 more
wiley   +1 more source

Novel preparation of cardiolipin from beef heart

Journal of Lipid Research, 1970
A new method is described for the isolation of beef heart cardiolipin. A lipid-protein complex, rich in cardiolipin, is obtained by a one-step solvent fractionation of the tissue total lipid extract. Cardiolipin in the complex is largely freed of protein
Joseph Eichberg, John D. Burnham
doaj   +1 more source

Differential Cardiolipin Hydrolysis by iPLA₂ and sPLA₂.

, 2013
The hydrolysis of cardiolipin by A. GVIA iPLA2, B. GIA sPLA2 and C. GV sPLA2 were examined in mixed micelle assays containing 100 µM cardiolipin and 400 µM Triton X-100 over a 100 min time course.
Darren S. Dumlao (393530), Edward A. Dennis (66784), Yuan-Hao Hsu (252386), Jian Cao (16485)   +3 more
core   +1 more source

A pro‐inflammatory cytokine signature characterises thrombotic antiphospholipid syndrome despite stable anticoagulation

British Journal of Haematology, EarlyView.
Primary antiphospholipid syndrome comprises distinct inflammatory subgroups defined by cytokine profiling. A shared pro‐inflammatory signature is present across all patients, whereas arterial thrombosis demonstrates enhanced inflammatory activation compared with venous thrombosis, suggesting divergent pathogenic mechanisms and opportunities for ...
Catherine B. Ducker, Megan V. Preece, Jeremy Schofield, Charis Pericleous, Mike Laffan, Simon Abrams, Deepa J. Arachchillage   +6 more
wiley   +1 more source