Results 21 to 30 of about 7,582 (165)

An essential bacterial-type cardiolipin synthase mediates cardiolipin formation in a eukaryote

, 2012
Cardiolipin is important for bacterial and mitochondrial stability and function. The final step in cardiolipin biosynthesis is catalyzed by cardiolipin synthase and differs mechanistically between prokaryotes and eukaryotes.
Bütikofer, Peter, Serricchio, Mauro
core   +1 more source

Highly Canalized MinD Transfer and MinE Sequestration Explain the Origin of Robust MinCDE-Protein Dynamics [PDF]

, 2012
Min-protein oscillations in Escherichia coli are characterized by the remarkable robustness with which spatial patterns dynamically adapt to variations of cell geometry.
Frey, Erwin, Erwin Frey, Jacob Halatek, Halatek, Jacob   +3 more
core   +1 more source

Cardiolipin’s Remodeling Rules Revealed: The Role of the Cellular Lipidome

Cell Reports, 2020
In this issue of Cell Reports, Oemer et al. (2020) define the acyl chain composition of cardiolipin and other lipid classes in murine tissues. They then employ artificial neural networks to predict mechanisms that govern cardiolipin tissue specificity ...
Olivia L. Sniezek, Arianna F. Anzmann, Steven M. Claypool, Hilary J. Vernon   +3 more
doaj   +1 more source

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

Nature Communications, 2018
Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin function can lead to spread of α-synuclein between neurons.
Tammy Ryan, Vladimir V. Bamm, Morgan G. Stykel, Carla L. Coackley, Kayla M. Humphries, Rhiannon Jamieson-Williams, Rajesh Ambasudhan, Dick D. Mosser, Stuart A. Lipton, George Harauz, Scott D. Ryan   +10 more
doaj   +1 more source

Acylation of monolysocardiolipin in rat heart

Journal of Lipid Research, 1999
Cardiolipin is a major mitochondrial membrane glycerophospholipid in the mammalian heart. In this study, the ability of the isolated intact rat heart to remodel cardiolipin and the mitochondrial enzyme activities that reacylate monolysocardiolipin to ...
Brian J. Ma, William A. Taylor, Vernon W. Dolinsky, Grant M. Hatch   +3 more
doaj   +1 more source

Immunological study on cardiolipin from Escherichia coli [PDF]

, 1968
For the first time we found that cardiolipin was contained abundantly in Eschrichia coli, and we succeeded in isolating and purifying it as reported previously. With this E.
Kanemasa, Yasuhiro
core   +1 more source

Analysis of neuronal cardiolipin and monolysocardiolipin from biological samples with cyclic ion mobility mass spectrometry

Frontiers in Physiology
The mitochondrial phospholipid cardiolipin (CL) is essential for proper mitochondrial function and energy production. Cardiolipin has four distinct fatty acid tails with varying expression compositions, resulting in a highly variable tissue-specific ...
Katlynn J. Emaus, Katlynn J. Emaus, Carmen A. Dunbar, Carmen A. Dunbar, Joseph Caruso, Brandon T. Ruotolo, Joseph M. Wider, Joseph M. Wider, Joseph M. Wider, Thomas H. Sanderson, Thomas H. Sanderson, Thomas H. Sanderson, Thomas H. Sanderson   +12 more
doaj   +1 more source

Cardiolipin Synthesis and Outer Membrane Localization Are Required for Shigella flexneri Virulence

mBio, 2017
Cardiolipin, an anionic phospholipid that resides at the poles of the inner and outer membranes, is synthesized primarily by the putative cardiolipin synthase ClsA in Shigella flexneri. An S.
Rachael M. Rossi, Lauren Yum, Hervé Agaisse, Shelley M. Payne   +3 more
doaj   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Microanalysis of cardiolipin in small biopsies including skeletal muscle from patients with mitochondrial disease

Journal of Lipid Research, 1999
Cardiolipin is a specific mitochondrial phospholipid that is present in mammalian tissues in low concentration. To measure cardiolipin in small biopsies from patients with mitochondrial disease, we developed a new technique that can detect subnanomolar ...
Michael Schlame, Sara Shanske, Steven Doty, Thomas König, Thomas Sculco, Salvatore DiMauro, Thomas J.J. Blanck   +6 more
doaj   +1 more source