Results 131 to 140 of about 36,776 (242)

Molecular and energetic basis of histidine switch dynamics in respiratory complex I

Protein Science, Volume 35, Issue 8, August 2026.
Abstract The respiratory complex I in mitochondria and bacteria drives the two‐electron reduction of quinone to pump protons across the membrane. The molecular basis of this catalytic reaction remains enigmatic despite significant progress in structural characterization of the complex.
Erik Endres, Mahdi Torabi, Mai Jousmäki, Kim Vy Huynh, Cristina Pecorilla, Oleksii Zdorevskyi, Volker Zickermann, Vivek Sharma   +7 more
wiley   +1 more source

Dual‐Laser Laser‐Induced Liquid Bead Ion Desorption Mass Spectrometry: A New Approach for Adjustable Softness and Higher Sensitivity

ChemPhysChem, Volume 27, Issue 14, 29 July 2026.
Native protein complexes often require gentle ionization to preserve weak interactions, yet higher ion yield typically goes hand in hand with increased in‐source dissociation. Our dual‐laser LILBID approach decouples ion production from dissociation by using two independently tunable pulses, enabling sample‐specific soft conditions and expanding access
Niko Popovic, Jonathan Schulte, Anne Mayer, Clemens Glaubitz, Nina Morgner   +4 more
wiley   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, Volume 13, Issue 39, 13 July 2026.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Ginsenoside Rg3 Restores Mitochondrial Cardiolipin Homeostasis via GRB2 to Prevent Parkinson's Disease

Advanced Science
Regulating cardiolipin to maintain mitochondrial homeostasis is a promising strategy for addressing Parkinson's disease (PD). Through a comprehensive screening and validation process involving multiple models, ginsenoside Rg3 (Rg3) as a compound capable ...
Li‐Feng‐Rong Qi, Shuai Liu, Qiuyuan Fang, Cheng Qian, Chao Peng, Yuci Liu, Peng Yang, Ping Wu, Ling Shan, Qinghua Cui, Qian Hua, Sen Yang, Cunqi Ye, Wei Yang, Ping Li, Xiaojun Xu   +15 more
doaj   +1 more source

cardiolipin

Citation: 'cardiolipin' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12989 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Relative Exchangeable Copper Confirms Wilson Disease and Supports Reclassification of the ATP7B p.Met665Ile Variant With Conflicting Pathogenicity Evidence

American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1691-1695, July 2026.
ABSTRACT Wilson disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B mutations. Diagnosis is usually straightforward in symptomatic patients, but can be challenging in children and adolescents with mild liver disease, borderline urinary copper excretion, or inconclusive genetic findings.
Emanuele Nicastro, Caterina Zuccoli, Roberto Marozzi, Antonino Barletta, Lisa Licini, Paola Tebaldi, Valeria Casotti, Mariangela Stinco, Lidia Pezzani, Maria Iascone, Lorenzo D'Antiga   +10 more
wiley   +1 more source

Plaat1 deficiency reduces cardiac cardiolipin content and impairs exercise tolerance

Journal of Lipid Research
Phospholipase A and acyltransferase 1 (PLAAT1) catalyzes O-transacylase, N-transacylase, and phospholipase A1/2 reactions. We have demonstrated that PLAAT1 has O-transacylase activity in vitro using phosphatidylcholine as an acyl donor and ...
Ashkan Hashemi, Ming Rong Liu, John Z. Chan, Antonia N. Berdeklis, Alex D. Cocco, Michelle V. Tomczewski, Douglas Strathdee, Ken D. Stark, Robin E. Duncan   +8 more
doaj   +1 more source

Decoding the Hot‐Mitochondrion Paradox

BioEssays, Volume 48, Issue 7, July 2026.
A distributed mechanism of mitochondrial heat generation is proposed in which all ion‐translocating proteins embedded within the inner mitochondrial membrane contribute to localized heat generation. All ion‐translocating proteins embedded within the inner mitochondrial membrane (IMM)—with ATP synthase shown here as an example—are proposed to function ...
Peyman Fahimi, Michael Lynch, Chérif F. Matta   +2 more
wiley   +1 more source

Advances in the Core Role and Mechanisms of Mitochondrial Dysfunction in Alzheimer's Disease

Brain and Behavior, Volume 16, Issue 7, July 2026.
In Alzheimer's disease, Aβ and Tau trigger mitochondrial dysfunction, driving a pathological cascade that results in cognitive decline. Gut microbiota dysbiosis exacerbates this via the gut–brain axis, making mitochondria a key therapeutic target. ABSTRACT Introduction Alzheimer's disease (AD) is a complex neurodegenerative disorder whose pathogenesis ...
Tianyi Gu, Hangyan Guo, Zixin Guo, Shengyu Hua   +3 more
wiley   +1 more source

A Case of Longitudinal Extensive Transversal Myelitis in Patient With Neuromyelitis Optica Spectrum Disorder and Systemic Lupus Erythematosus

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune, demyelinating disorder of the central nervous system. Clinical manifestations include optic neuritis, longitudinally extensive transverse myelitis (LETM) involving three or more vertebral segments, and, in most cases, seropositivity for anti‐aquaporin‐4 antibodies (AQP4‐IgG).
Nikolina Pravdic, Marijana Goluza, Natasa Pejanovic Skobic, Davor Batinic, Jelena Zovko, Tanja Zovko, Anita Ivankovic, Inge Klupka Saric   +7 more
wiley   +1 more source