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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Cardiolipin (CL) is recognized to be an essential phospholipid in eukaryotic energy metabolism so that physiological and pathological perturbations in its synthetic and catabolic pathways play key roles in maintaining mitochondrial structure and function, and ultimately cell survival.
Jeanie B, McMillin, William, Dowhan
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Cardiolipin (CL) is recognized to be an essential phospholipid in eukaryotic energy metabolism so that physiological and pathological perturbations in its synthetic and catabolic pathways play key roles in maintaining mitochondrial structure and function, and ultimately cell survival.
Jeanie B, McMillin, William, Dowhan
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Studies of the cardiolipin interactome
Progress in Lipid Research, 2022Cardiolipin (CL) is a unique phospholipid that is fundamental to the structure and function of the highly curved cristae membranes of mitochondria. Given its distinctive cone-shaped molecular architecture, CL induces negative membrane curvature in a bilayer setting.
Colin A, Fox, Robert O, Ryan
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Cholesterol effects on the interaction of cardiolipin with anti-cardiolipin antibody
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1987Human antibodies to cardiolipin, phosphatidic acid and phosphatidylserine were assessed by binding to nitrocellulose paper and subsequent reaction with an enzyme-linked or radioactively labelled second antibody to human IgG. The addition of cholesterol to constant amounts of cardiolipin impregnated in the nitrocellulose paper resulted in a profound ...
P B, Costello, F A, Green
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Cardiolipin Remodeling in the Heart
Journal of Cardiovascular Pharmacology, 2009Cardiolipin (CL) is a mitochondrial phospholipid that fundamentally contributes to the function of many proteins in the inner mitochondrial membrane, where it is actively involved in the integrity and flux of the electron transport chain. In the heart, functional CL is linoleic acid rich, and the loss of linoleic acid content is associated with cardiac
Genevieve C, Sparagna +1 more
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Photoreactive cardiolipin analogues
Chemistry and Physics of Lipids, 1988New photoreactive analogues of cardiolipin have been chemically synthesized. Photoreactive aryl azido acyl groups were placed at two different locations within the cardiolipin molecule: at the 2-sn position of the 2-sn glycerol of cardiolipin; at the 2-sn position of the 3-sn-phosphatidyl group; or at both locations to provide a dual labeled analogue ...
W T, Fowler, J D, Lambeth, G L, Powell
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Labelling of cardiolipin in vitro
Chemistry and Physics of Lipids, 1979A method for labelling the polar head groups of cardiolipin is described. Labelling was carried out on sonicated cardiolipin/water suspensions. The free hydroxyl group of cardiolipin was oxidised with an excess of p-(diazonium) benzenesulfonic acid (DABS) and then reduced with NaB3H4.
E, Viola, M, Beltrame, P, Arslan
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Mammalian cardiolipin biosynthesis
Chemistry and Physics of Lipids, 2014Cardiolipin is a major phospholipid in mitochondria and is involved in the generation of cellular energy in the form of ATP. In mammalian and eukaryotic cells it is synthesized via the cytidine-5'-diphosphate-1,2-diacyl-sn-glycerol phosphate pathway. This brief review will describe some of the more recent studies on mammalian cardiolipin biosynthesis ...
Edgard M, Mejia +2 more
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Biosynthesis of Cardiolipin in Mitochondria
Canadian Journal of Biochemistry, 1971Conversion of sn-glycero-3-phosphate-2-3H to cardiolipin in mitochondria isolated from guinea pig liver has been established. Cardiolipin thus formed was isolated and characterized. Under similar conditions, microsomes were not able to catalyze the biosynthesis of cardiolipin in a detectable amount. The mechanism for the biosynthesis of cardiolipin in
J B, Davidson, N Z, Stanacev
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2007
Publisher Summary This chapter focuses on the most useful methods for cardiolipin analysis and discusses their respective merits and shortcomings. Regardless of the technical details, the key to each method is the separation of cardiolipin from the other lipids that are present in biological tissues.
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Publisher Summary This chapter focuses on the most useful methods for cardiolipin analysis and discusses their respective merits and shortcomings. Regardless of the technical details, the key to each method is the separation of cardiolipin from the other lipids that are present in biological tissues.
openaire +2 more sources