Results 91 to 100 of about 297,969 (261)

Serial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice

Advanced Science, EarlyView.
A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.
Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill   +12 more
wiley   +1 more source

Real-World Assessment of the Association Between PCSK9i Adherence and LDL Reduction and Variability in a Chinese Clinical Practice

Clinical Epidemiology
Xiaomin Ye,1,2,* Shaozhao Zhang,1,2,* Xiangbin Zhong,1,2 Miaohong Li,1,2 Menghui Liu,1,2 Xiaodong Zhuang,1,2 Xinxue Liao1,2 1Cardiology Department, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China ...
Ye X, Zhang S, Zhong X, Li M, Liu M, Zhuang X, Liao X   +6 more
doaj  

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: executive summary

, 2010
With advances in pediatric cardiology and cardiac surgery, the population of adults with congenital heart disease (CHD) has increased. In the current era, there are more adults with CHD than children.
Oechslin, Erwin, Meijboom, Folkert, Landzberg, Mike, Mital, Seema, Benson, Lee, Gary Webb, Dore, Annie, Omid Salehian, Timothy Bradley, Michael Connelly, Paul Khairy, Greutmann, Matthias, Marla Kiess, Webb, Gary, Barbara Mulder, Khairy, Paul, Celermajer, David, Louise Harris, Markus Schwerzmann, Luc Beauchesne, Baumgartner, Helmut, Lee Benson, Isabelle Vonder Muhll, Annie Dore, Silversides, Candice K., Beauchesne, Luc, Dylan Taylor, Ariane Marelli, David Celermajer, Connelly, Michael, Warnes, Carole, Judith Therrien, Carole Warnes, Mike Landzberg, Schwerzmann, Markus, Helmut Baumgartner, Vonder Muhll, Isabelle, Seema Mital, Eric Horlick, Matthias Greutmann, Mulder, Barbara, Jack Colman, Harris, Louise, Taylor, Dylan, Kiess, Marla, Folkert Meijboom, Nancy Poirier, Candice K. Silversides, Niwa, Koichiro, Erwin Oechslin, Horlick, Eric, Marelli, Ariane, Colman, Jack, Bradley, Timothy, Poirier, Nancy, Koichiro Niwa, Salehian, Omid, Therrien, Judith, Silversides, Candice K   +58 more
core   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Linking Metabolic and Mitochondrial Stress to Regulated Cell Death and Inflammatory Organ Injury in Sepsis

Journal of Inflammation Research
Guohairong Pan,1,* Lulu Zhou,2,* Ruochong Wang,1,* Fei Gao,3 Shuai Li,4 Jingwei Kong,1 Chen Xin,1 Liangyu Cui,1 Xingyu Zhao,1 Liying Wang11Research Center for Standards of Traditional Chinese Medicine, Institute of Basic Research ...
Pan G, Zhou L, Wang R, Gao F, Li S, Kong J, Xin C, Cui L, Zhao X, Wang L   +9 more
doaj  

Role of Rotablation in interventional cardiology

, 2018
With the increasing calcification of plaques, especially in the older population and those with multiple comorbidities, interventional cardiology has faced a lot of challenges. Rotational Atherectomy is type of percutaneous coronary intervention used in
Issack, Barke Mohamed
core  

Role of myeloperoxidase in cardiology

, 2010
Myeloperoxidase (MPO) is an enzyme found in myeloid cells, particularly in neutrophils, and to a lesser extent in monocytes and tissue macrophages. MPO plays an important role in the host defense against bacteria and viruses.
Karadag, Bilgehan, Ikitimur, Baris, Bilgehan Karadag, Baris Ikitimur   +3 more
core   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Regulatory Effects of Zhenxin Formula in Treating Doxorubicin-Induced Heart Failure: Network Pharmacology and Animal Experimental Verification

Drug Design, Development and Therapy
Qiong Wu,1,* Hao Wang,2,* You Hua Wang,1 Jun Du,3 Bo Li,3 Xiao-Na Gan,3 Chen-Yang Liu,2 Jing Liang,2 Chang Liu,2 Min Cao2 1Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine ...
Wu Q, Wang H, Wang YH, Du J, Li B, Gan XN, Liu CY, Liang J, Liu C, Cao M   +9 more
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