Results 41 to 50 of about 413,528 (329)

Enabling Precision Cardiology Through Multiscale Biology and Systems Medicine

JACC: Basic to Translational Science, 2017
Summary: The traditional paradigm of cardiovascular disease research derives insight from large-scale, broadly inclusive clinical studies of well-characterized pathologies.
Kipp W. Johnson, BS, Khader Shameer, PhD, Benjamin S. Glicksberg, BS, Ben Readhead, MBBS, Partho P. Sengupta, MD, Johan L.M. Björkegren, MD, PhD, Jason C. Kovacic, MD, PhD, Joel T. Dudley, PhD   +7 more
doaj   +1 more source

The role of endothelin-1 in pulmonary arterial hypertension. [PDF]

, 2014
Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left untreated rapidly progresses to right ventricular failure and eventually death. In the quest to understand the pathogenesis of this disease differences in the profile,
Chester, AH, Yacoub, MH
core   +1 more source

Intact fibroblast growth factor 23 in heart failure with reduced and mildly reduced ejection fraction

BMC Cardiovascular Disorders, 2023
Background Fibroblast growth factor-23 (FGF23) has been associated to left ventricular (LV) hypertrophy and heart failure (HF) severity. We aimed to investigate the clinical correlates and prognostic value of intact FGF23 (iFGF23) in HF patients. Methods
Giuseppe Vergaro, Annamaria Del Franco, Alberto Aimo, Francesco Gentile, Vincenzo Castiglione, Federica Saponaro, Silvia Masotti, Concetta Prontera, Niccolò Fusari, Michele Emdin, Claudio Passino   +10 more
doaj   +1 more source

Intraventricular synchronism assessment by gated-SPECT myocardial perfusion imaging in cardiac resynchronization therapy. Does cardiomyopathy type influence results?

EJNMMI Research, 2020
Purpose To analyze the evolution post-cardiac resynchronization therapy (CRT) in left ventricular non-compaction (LVNC) cardiomyopathy (CM) patients compared to other types of CM, according to clinical and functional variables, by using gated-SPECT ...
Amalia Peix, Kenia Padrón, Lázaro O. Cabrera, Osmín Castañeda, Danet Milán, Jesús Castro, Roylan Falcón, Frank Martínez, Lydia Rodríguez, Jesús Sánchez, Erick Mena, Regla Carrillo, Yoel Fernández, Ricardo Escarano, Diana Páez, Maurizio Dondi   +15 more
doaj   +1 more source

Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose–response meta-analysis of prospective studies [PDF]

, 2017
Different adiposity measures have been associ- ated with increased risk of atrial fibrillation, however, results have previously only been summarized for BMI. We therefore conducted a systematic review and meta- analysis of prospective studies to clarify
Aune, D, Janszky, I, Norat, T, Riboli, E, Romundstad, P, Schlesinger, S, Sen, A, Tonstad, S, Vattan, LJ   +8 more
core   +1 more source

Cardiogenic Shock

Majalah Kardiologi Indonesia
In “Cardiogenic Shock” (Indonesian Journal of Cardiology, 43(2), 90-9. https://doi.org/10.30701/ijc.1505), there are an errors noted. An error has been found in the PDF version of this article. The DOI printed in the PDF is incorrect. The correct DOI
H. P. Bagaswoto, D. A. Juzar, F. Habib, Y. S. Bramantyo, P. N. P. P. Sanggula, A. Z. Widiastuti   +5 more
doaj   +1 more source

Personalized medicine—a modern approach for the diagnosis and management of hypertension [PDF]

, 2017
The main goal of treating hypertension is to reduce blood pressure to physiological levels and thereby prevent risk of cardiovascular disease and hypertension-associated target organ damage.
Borghi, Claudio, Grassi, Guido, Rosei, Enrico Agabiti, Savoia, Carmine, Touyz, Rhian M., Volpe, Massimo   +5 more
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Development and Utility of Quality Metrics for Ambulatory Pediatric Cardiology in Kawasaki Disease. [PDF]

, 2020
The Adult Congenital and Pediatric Cardiology (ACPC) Section of the American College of Cardiology sought to develop quality indicators/metrics for ambulatory pediatric cardiology practice.
Cotts, Timothy, Dahdah, Nagib, Davidson, Alex, Harahsheh, Ashraf S, Johnson, Walter H, Jone, Pei-Ni, Mensch, Deborah J, Newburger, Jane W, Portman, Michael A, Sutton, Nicole, Tani, Lloyd Y, Teitel, David F   +11 more
core   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source