Results 171 to 180 of about 4,979,977 (315)

Benchmarking gut microbiome indices within and across populations

iMetaOmics, EarlyView.
We compared 10 widely used gut microbiome indices in 12,561 American Gut Project participants and 10 external cohorts, testing how well each distinguished people with healthy lifestyles, responded to 79 environmental factors, and associated with 14 chronic conditions. No single index performed best on all three tasks.
Yu Sun, Yuwei Tang, Jieying Ou, Xinghan Wang, Yiwen Yuan, Xi Fu, Yiqun Deng   +6 more
wiley   +1 more source

Substituting Low-Calorie Sweetened Beverages for Sugar-Sweetened Beverages to Prevent Obesity and Cardiometabolic Diseases: Still a Good Idea? [PDF]

Low-calorie sweeteners (LCSs) and LCS-containing beverages have been proposed as appropriate substitutes for caloric sugars in recent years. In this Perspective, we highlight the recent findings from observational and interventional studies, focusing on ...
Raeisi-Dehkordi, Hamidreza, Chatelan, Angeline, Salehi-Abargouei, Amin   +2 more
core  

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Postoperative association between impaired renal function and vascular dysfunction in liver transplant recipients

, 2022
Liver Transplantation, EarlyView.
Domenico A. Chavez, Marie‐Claire Evans, Natalie J. Bohmke, Hiba Kamal, Loan Quynh Tran, Chandra Bhati, Susan Wolver, Mohammad S. Siddiqui, Danielle L. Kirkman   +8 more
wiley   +1 more source

EFFECTS OF TOFACITINIB ON CARDIOMETABOLIC SYNDROME

Tofacitinib has been approved for some various inflammatory and autoimmune diseases. These inflammatory and autoimmune processes play important roles in the pathogenesis of cardiometabolic conditions.
SEBUCHU, VICPAUL LWAMBA
core  

Editorial: Cardiometabolic diseases in understudied populations

Frontiers in Epidemiology, 2023
Liliana Aguayo, Andrea López-Cepero, Xiao Tan, Xiao Tan, Mayra L. Estrella, Victor W. Zhong   +5 more
openaire   +4 more sources

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Paracetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long‐term metabolic and reproductive consequences linked to intrauterine paracetamol exposure.
Bita Entezari, Deniz Bozdag, Elif İnce‐Erguc, Aylin Buhur, Cansin Sirin Tomruk, Suna Sabuncuoglu, Altug Yavasoglu, Hande Gurer‐Orhan   +7 more
wiley   +1 more source

Diet Versus Exercise in Cardiometabolic Disease: Are Two Always Better Than One? [PDF]

Curr Cardiol Rep
Jo J, Lee K.
europepmc   +1 more source