Results 231 to 240 of about 147,725 (290)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang   +18 more
wiley   +1 more source

Frailty and transitions across cardiometabolic disease states: evidence from multistate models in a 16-year Chinese cohort. [PDF]

open access: yesNPJ Aging
Zhang RH   +11 more
europepmc   +1 more source

Timing of Delivery in Preeclampsia: Time to Reconsider?

open access: yes
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
Rebecca Horgan   +5 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

open access: yesBritish Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska   +2 more
wiley   +1 more source

Effect Modification by Cofactors in the Impact of Body Mass Index Change on the Risk of Lung Cancer

open access: yesCancer Science, EarlyView.
Persistent overweight or obesity, and BMI gain from normal to overweight or obesity, were consistently associated with reduced lung cancer risk, with stronger associations among men and ever smokers. Persistent underweight and BMI loss were associated with increased lung cancer risk, particularly in men. The protective effect of obesity and BMI gain is
Su Youn Nam, Junwoo Jo, Sun Ha Choi
wiley   +1 more source

Extreme Heat, Social Factors, and Mortality Among California Veterans With Cardiometabolic Disease.

open access: yesJAMA Netw Open
Shannon EM   +6 more
europepmc   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

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