Results 221 to 230 of about 123,173 (290)

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis [PDF]

, 2018
et al.,, Rao, D. C, Schwander, Karen
core   +1 more source

Physical Activity, Sleep and Sedentary Behaviour of Adults With Intellectual Disabilities, Family Caregivers and Service Providers During COVID‐19 Pandemic Recovery

British Journal of Learning Disabilities, EarlyView.
ABSTRACT Background Guidelines outline recommended amounts of physical activity (PA), sleep and sedentary time for optimal health. Research suggests that adults with intellectual disabilities (ID) often do not meet recommendations and that engagement in healthy behaviours is impacted by those around them. The COVID‐19 pandemic amplified these concerns.
Laura C. Koch, Yona Lunsky, Kathleen Tremells, Tiziana Volpe, Anupam Thakur, Johanna Lake, Laura St. John   +6 more
wiley   +1 more source

The Association Between the Hemoglobin Glycation Index and Cardiometabolic Diseases: A Mini-Review. [PDF]

J Clin Hypertens (Greenwich)
Wu QY, Mo LR, Nan J, Huang WZ, Wu Q, Su Q.   +5 more
europepmc   +1 more source

The use of different types of networks, alone and in combination, for drug target identification

British Journal of Pharmacology, EarlyView.
Current therapeutic approaches often focus on targeting clinical symptoms or peripheral phenotypes rather than the underlying molecular mechanisms, or endophenotypes, that drive diseases. While symptom‐based drugs can alleviate discomfort, they do not necessarily alter disease progression and may overlook opportunities for prevention or early ...
Paolo Parini
wiley   +1 more source

Multi-trait association analysis reveals shared genetic architecture between lung cancer and cardiometabolic diseases. [PDF]

iScience
Lyu Q, Wang XY, Chen E, Sun C, Qiu Z, Xie Y, He P.   +6 more
europepmc   +1 more source

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Associations of gestational diabetes mellitus with the risk of cardiometabolic diseases: results from NHANES and mendelian randomization analyses. [PDF]

Diabetol Metab Syndr
Zhang L, Qiu Y, Huang Y, Ainiwan D, Zhou H, Cheng H, Alifu X, Zhuang Y, Chi P, Chen D, Liu H, Yu Y.   +11 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Perspectives on whole body and tissue-specific metabolic flexibility and implications in cardiometabolic diseases. [PDF]

Cell Rep Med
Ang JC, Sun L, Foo SR, Leow MK, Vidal-Puig A, Fontana L, Dalakoti M.   +6 more
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source