Results 11 to 20 of about 89,014 (119)

Early High-Fat Diet Exposure Causes Dysregulation of the Orexin and Dopamine Neuronal Populations in Nonhuman Primates

Frontiers in Endocrinology, 2018
Maternal obesity and consumption of a high-fat diet (HFD) during pregnancy has a negative impact on offspring, including an increased risk for the development of obesity in adolescence.
Cadence True, Anam Arik, Sarah Lindsley, Melissa Kirigiti, Elinor Sullivan, Elinor Sullivan, Paul Kievit   +6 more
doaj   +1 more source

Treatment with acetate during late pregnancy protects dams against testosterone-induced renal dysfunction

Heliyon, 2021
Cardiometabolic diseases are complicated by renal damage. Gestational hyperandrogenism causes gestational metabolic dysfunction that is associated with fetal and maternal tissue derangements as well as post-partum maternal androgen excess.
Lawrence A. Olatunji, Emmanuel D. Areola, Taofeek O. Usman, Olufunto O. Badmus, Kehinde S. Olaniyi   +4 more
doaj   +1 more source

Expression of whole blood miR-126-3p, -30a-5p, -1299, -182-5p and -30e-3p in chronic kidney disease in a South African community-based sample

Scientific Reports, 2022
The burden of chronic kidney disease (CKD) in Africa remains poorly characterized, due partly to the lack of appropriate diagnostic strategies. Although in recent years the diagnostic and prognostic utility of microRNAs (miRNAs) have gained prominence in
Dipuo D. Motshwari, Cindy George, Don M. Matshazi, Cecil J. Weale, Saarah F. G. Davids, Annalise E. Zemlin, Rajiv T. Erasmus, Andre P. Kengne, Tandi E. Matsha   +8 more
doaj   +1 more source

Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons

Molecular Metabolism, 2019
Objective: Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophrenia ...
Brandon L. Roberts, Baylin J. Bennett, Camdin M. Bennett, Julie M. Carroll, Louise S. Dalbøge, Colin Hall, Wafa Hassouneh, Kristy M. Heppner, Melissa A. Kirigiti, Sarah R. Lindsley, Katherine G. Tennant, Cadence A. True, Andrew Whittle, Anitra C. Wolf, Charles T. Roberts, Jr., Mads Tang-Christensen, Mark W. Sleeman, Michael A. Cowley, Kevin L. Grove, Paul Kievit   +19 more
doaj   +1 more source

The Relationship between the Oral Microbiota and Metabolic Syndrome

Biomedicines, 2022
The oral microbiota plays a crucial role in both systemic inflammation and metabolic syndrome (MetS), which is characterised by low-grade inflammation. Studies have analysed the gut microbiota using stool specimens from subjects with MetS; however, the ...
Yvonne Prince, Glenda M. Davison, Saarah F. G. Davids, Rajiv T. Erasmus, Andre P. Kengne, Lisa M. Graham, Shanel Raghubeer, Tandi E. Matsha   +7 more
doaj   +1 more source

Does insomnia worsen cardiometabolic health?

Advances in Clinical Neuroscience & Rehabilitation, 2019
Insomnia is thought to affect 5-10% of the general population and is associated with daytime impairment and distress. Insomniacs were found to have a higher risk of poor cardiometabolic health.
Gewei Zhu, Kirstie Anderson
doaj   +1 more source

The interplay of climate change and physical activity: Implications for cardiovascular health

American Heart Journal Plus
Cardiovascular disease (CVD) is one of the top contributors to global disease burden. Meeting the physical activity guidelines can effectively control and prevent several CVD risk factors, including obesity, hypertension and diabetes mellitus.
Eloise J. Thompson, Sarah E. Alexander, Kegan Moneghetti, Erin J. Howden   +3 more
doaj   +1 more source

Cardiometabolic diseases, frailty, and healthcare utilization and expenditure in community-dwelling Chinese older adults

Scientific Reports, 2021
This study investigated associations between cardiometabolic diseases, frailty, and healthcare utilization and expenditure among Chinese older adults. The participants were 5204 community-dwelling adults aged at least 60 years from the China Health and ...
Ke Gao, Bo-Lin Li, Lei Yang, Dan Zhou, Kang-Xi Ding, Ju Yan, Ya-Jie Gao, Xiao-Rui Huang, Xiao-Pu Zheng   +8 more
doaj   +1 more source

Neck circumference is independently associated with relative systemic hypertension in young adults with sickle cell anaemia

Clinical Hypertension, 2018
Background A seemingly interesting observation in patients with sickle cell anaemia (SCA) is that they usually have lower systemic blood pressures (BP) and insulin resistance than persons in the general population in spite of chronic inflammation and ...
Lawrence A. Olatunji, Olatunde P. Olabode, Olawale M. Akinlade, Abiola S. Babatunde, Victoria A. Olatunji, Ayodele O. Soladoye   +5 more
doaj   +1 more source

Expression Profiles of Circulating microRNAs in South African Type 2 Diabetic Individuals on Treatment

Frontiers in Genetics, 2021
Aim: The influence of disease duration and anti-diabetic treatment on epigenetic processes has been described, with limited focus on interactions with microRNAs (miRNAs).
Cecil J. Weale, Don M. Matshazi, Saarah F. G. Davids, Shanel Raghubeer, Rajiv T. Erasmus, Andre P. Kengne, Andre P. Kengne, Glenda M. Davison, Tandi E. Matsha   +8 more
doaj   +1 more source