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Autoimmune diseases (ADs) are characterized by the activation of the immune system against self-antigens. More common in women than in men and with an early onset, their incidence is increasing worldwide, and this, combined with their chronic nature, is ...
Olga Martinez-Arroyo +3 more
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Rab3A/Rab27A System Silencing Ameliorates High Glucose-Induced Injury in Podocytes
Diabetic nephropathy is a major complication in diabetic patients. Podocytes undergo loss and detachment from the basal membrane. Intra- and intercellular communication through exosomes are key processes for maintaining function, and the Rab3A/Rab27A ...
Olga Martinez-Arroyo +5 more
doaj +1 more source
Cardiometabolic Disease Risk in Normal Weight Obesity and Exercise Interventions for Proactive Prevention [PDF]
PURPOSE Normal weight obesity (NWO) is characterized by a normal body mass index but a high body fat mass percentage and low skeletal muscle mass, thereby increasing the risk of cardiometabolic dysfunction and morbidity.
Minje Ji, Chaeeun Cho, Sewon Lee
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Background: Per- and polyfluoroalkyl substances (PFAS) may adversely influence cardiometabolic risk. However, few studies have examined if the timing of early life PFAS exposure modifies their relation to cardiometabolic risk.
Nan Li +11 more
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Optimization of small RNA library preparation protocol from human urinary exosomes
Background Sequencing of miRNAs isolated from exosomes has great potential to identify novel disease biomarkers, but exosomes have low amount of RNA, hindering adequate analysis and quantification.
Dolores Olivares +5 more
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Health disparities in cardiometabolic risk among Black and Hispanic youth in the United States
Cardiometabolic risk factors in children and adolescents track into adulthood and are associated with increased risk of atherosclerotic cardiovascular disease.
Sophia Figueroa Katz +2 more
doaj +1 more source
Exosomes, nanometer-sized lipid-bilayer-enclosed extracellular vesicles (EVs), have attracted increasing attention due to their inherent ability to shuttle proteins, lipids and genes between cells and their natural affinity to target cells.
Ana Ortega +3 more
doaj +1 more source
Background Cardiometabolic health has been worsening among young adults, but the prevalence of lifestyle risk factors and cardiometabolic diseases is unclear.
Shuxiao Shi +4 more
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There is little research on how long-term exposure to independent and multiple air pollutants changes cardiometabolic risk in adults. In addition, previous studies focused on only the effect of one or two lifestyles on cardiometabolic risk.
Xueyan Wu +11 more
doaj +1 more source
Urinary exosome miR-146a is a potential marker of albuminuria in essential hypertension
Background There is increasing interest in using extracellular vesicle-derived microRNAs (miRNAs) as biomarkers in renal dysfunction and injury. Preliminary evidence indicates that miRNAs regulate the progression of glomerular disease.
Javier Perez-Hernandez +8 more
doaj +1 more source

