Results 71 to 80 of about 305,984 (384)

Human-induced pluripotent stem cells in modeling inherited cardiomyopathies

Journal of the Practice of Cardiovascular Sciences, 2015
Our current understanding of molecular mechanisms of cardiomyopathies has been elucidated from genetic animal models. Induced pluripotent stem cells (iPSCs) can provide a platform to improve our understanding of familial cardiomyopathies diseases.
Subhoshree Ghose, Anju Sharma, Aishwarya Agarwal, Shantanu Sengupta   +3 more
doaj   +1 more source

Testosterone, cardiomyopathies, and heart failure: a narrative review

Asian Journal of Andrology, 2021
Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling ...
R. Diaconu, Ionut Donoiu, O. Mirea, T. Bălșeanu   +3 more
semanticscholar   +1 more source

Cardiac manifestations of PRKAG2 mutation. [PDF]

, 2018
BACKGROUND:The Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2 (PRKAG2) cardiac syndrome is characterized by glycogen accumulation in the cardiac tissue.
Ardehali, Reza, Banankhah, Pooya, Dota, Anthony, Fishbein, Gregory A   +3 more
core   +1 more source

Cardiomyopathies [PDF]

Circulation Research, 2017
The nonischemic cardiomyopathies are a diverse group of cardiac disorders that frequently cause heart failure and death and are now recognized with increasing frequency. There has been substantial progress in the clinical recognition and understanding of the natural history of these conditions. Well-established and new techniques of cardiac imaging are
openaire   +2 more sources

Exploring TTN variants as genetic insights into cardiomyopathy pathogenesis and potential emerging clues to molecular mechanisms in cardiomyopathies

Scientific Reports
The giant protein titin (TTN) is a sarcomeric protein that forms the myofibrillar backbone for the components of the contractile machinery which plays a crucial role in muscle disorders and cardiomyopathies.
Amir Ghaffari Jolfayi, E. Kohansal, Serwa Ghasemi, Niloofar Naderi, Mahshid Hesami, Mohammadhossein Mozafarybazargany, Maryam Hosseini Moghadam, Amir Farjam Fazelifar, Majid Maleki, Samira Kalayinia   +9 more
semanticscholar   +1 more source

Novel compound mutations in the mitochondrial translation elongation factor (TSFM) gene cause severe cardiomyopathy with myocardial fibro-adipose replacement [PDF]

, 2019
Primary mitochondrial dysfunction is an under-appreciated cause of cardiomyopathy, especially when cardiac symptoms are the unique or prevalent manifestation of disease.
Bonnen, Penelope E, Carbo, Miriam, Cerbelli, Bruna, D'Amati, Giulia, Della Monica, Paola Lilla, Falkous, Gavin, Giordano, Carla, Glasgow, Ruth I C, Hardy, Steven A, He, Langping, Morea, Veronica, Perli, Elena, Pignataro, Maria Gemma, Pisano, Annalinda, Re, Federica, Taylor, Robert W, Zacara, Elisabetta   +16 more
core   +2 more sources

Assessing the Applicability of Cardiac Myosin Inhibitors for Hypertrophic Cardiomyopathy Management in a Large Single Center Cohort

Reviews in Cardiovascular Medicine
Background: Cardiac myosin inhibitors (CMIs), including Mavacamten and Aficamten, have emerged as a groundbreaking treatment for hypertrophic cardiomyopathy (HCM).
Ali Amr, Elham Kayvanpour, Christoph Reich, Jan Koelemen, Shamily Asokan, Norbert Frey, Benjamin Meder, Farbod Sedaghat-Hamedani   +7 more
doaj   +1 more source

Sudden Death and Left Ventricular Involvement in Arrhythmogenic Cardiomyopathy [PDF]

, 2019
BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized by myocardial fibrofatty replacement and an increased risk of sudden cardiac death (SCD).
Asimaki, A, Basu, J, Behr, ER, Cook, SA, Ensam, B, Finocchiaro, G, Gray, B, Malhotra, A, Miles, C, Papadakis, M, Papatheodorou, E, Parry-Williams, G, Paterson, C, Robertus, JL, Sharma, S, Sheppard, MN, Ster, IC, Tome, M, Ware, JS, Westaby, J, Witney, A   +20 more
core   +1 more source

Targeting ferroptosis as a promising therapeutic strategy to treat cardiomyopathy

Frontiers in Pharmacology, 2023
Cardiomyopathies are a clinically heterogeneous group of cardiac diseases characterized by heart muscle damage, resulting in myocardium disorders, diminished cardiac function, heart failure, and even sudden cardiac death.
Huiyan Sun, Huiyan Sun, Dandan Chen, Wenjing Xin, Lixue Ren, Qiang LI, Xuchen Han   +6 more
doaj   +1 more source

Complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine

The Journal of General Physiology, 2021
Thousands of variants are associated with genetic cardiomyopathies; however, the mechanisms driving these progressive, heterogeneous diseases are not well understood.
M. Greenberg, J. Tardiff
semanticscholar   +1 more source