Results 241 to 250 of about 120,376 (304)

Cardiomyopathy genetic testing: insights into demographics, counseling, and cascade screening. [PDF]

Future Cardiol
Bui QM, Silver E, Argiro A, Murray S, Korty L, Silva Enciso J, Urey MA, Chi NC, Hong KN, Adler ED.   +9 more
europepmc   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

A case report of non-lamin A/C dilated cardiomyopathy presenting in a patient with Najjar-Malouf syndrome. [PDF]

Eur Heart J Case Rep
Flury G, Arquint F.
europepmc   +1 more source

Matrix metalloproteinase inhibition protects against junctophilin‐2 proteolysis during doxorubicin‐induced cardiotoxicity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Treatment of cancer patients with anthracyclines is known to cause dose‐dependent cardiotoxicity through several mechanisms including enhanced oxidative stress, ultimately resulting in defective excitation–contraction coupling.
Wesam Bassiouni, Brandon Y. H. Chan, Andrej Roczkowsky, Joshua W. Kranrod, Zabed Mahmud, Joseph O. Primeau, Woo Jung Cho, Howard S. Young, John M. Seubert, Richard Schulz   +9 more
wiley   +1 more source

Left bundle branch block-induced pseudo-infarction: Cardiac MRI pitfall. [PDF]

Acta Radiol Open
Flynn S, Killick D, McDonald K, Dodd J.
europepmc   +1 more source

Dexrazoxane protects against doxorubicin‐induced cardiotoxicity in susceptible human living myocardial slices: A proof‐of‐concept study

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The increasing number of cancer survivors has caused growing concern over chemotherapy‐induced cardiotoxicity. This study aimed to investigate a novel human model of cardiotoxicity and explore cardioprotection. Experimental Approach Living myocardial slices (LMS) were obtained from explanted end‐stage heart failure ...
Jort S. A. van der Geest, Ilse R. Kelters, Bauke Arends, Willem B. van Ham, Ernest Diez Benavente, Thirza A. Lapré, Petra van der Kraak, Pim van der Harst, Arco J. Teske, Andreas Dendorfer, M. Mostafa Mokhles, Pieter A. Doevendans, Teun P. de Boer, Linda W. van Laake, Joost P. G. Sluijter, Vasco Sampaio‐Pinto   +15 more
wiley   +1 more source

Shape of the mitral annulus in normal individuals and dilated cardiomyopathies: computational modeling insights into leaflet stress distribution. [PDF]

Front Physiol
Pasta S, La Franca E, Crascì F, Gentile G, Cipriani M, Faletra FF.   +5 more
europepmc   +1 more source

Opioid receptors in cardiovascular function

British Journal of Pharmacology, EarlyView.
Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari, Kesha K. Dalal, Narendra Kondapalli, Sailaja Paruchuri, Charles K. Thodeti   +4 more
wiley   +1 more source

Machine Learning Algorithm-Based Discovery of Potential Regulators of Immune-Related Dilated Cardiomyopathy. [PDF]

Acta Cardiol Sin
Yang YT, Zhen B, Cao X, Xia HY, Gong YZ, Yang YL.   +5 more
europepmc   +1 more source

CTCF Point Mutation at R567 Disrupts Mouse Heart Development via 3D Genome Rearrangement and Transcription Dysregulation

Cell Proliferation, Volume 58, Issue 4, April 2025.
The CtcfR567W/R567W mutation disrupted the TAD structure specific to cardiac genes and reduced the interaction between the promoter of cardiac‐specific gene and its enhancer, finally causing the cardiac morphological abnormalities during mouse embryonic development.
Huawei Ren, Hongxin Zhong, Jie Zhang, Yuli Lu, Gongcheng Hu, Weixun Duan, Ning Ma, Hongjie Yao   +7 more
wiley   +1 more source