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Dilated cardiomyopathy: causes, mechanisms, and current and future treatment approaches
Lancet, The, 2023Dilated cardiomyopathy is conventionally defined as the presence of left ventricular or biventricular dilatation or systolic dysfunction in the absence of abnormal loading conditions (eg, primary valve disease) or significant coronary artery disease ...
Stéphane Heymans +2 more
exaly +2 more sources
Circulation Research, 2017
Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal, sarcomere, and nuclear envelope proteins, among others, account for up to 35% of cases. Acquired causes include myocarditis and exposure to alcohol, drugs and toxins, and metabolic and
Elizabeth M Mcnally
exaly +4 more sources
Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal, sarcomere, and nuclear envelope proteins, among others, account for up to 35% of cases. Acquired causes include myocarditis and exposure to alcohol, drugs and toxins, and metabolic and
Elizabeth M Mcnally
exaly +4 more sources
Single-nuclei profiling of human dilated and hypertrophic cardiomyopathy
Nature, 2022Heart failure encompasses a heterogeneous set of clinical features that converge on impaired cardiac contractile function1,2 and presents a growing public health concern.
M. Chaffin +18 more
semanticscholar +1 more source
Screening for dilated cardiomyopathy in dogs.
Journal of Veterinary Cardiology, 2021BACKGROUND Dilated cardiomyopathy (DCM) is the most common cardiac disease in large breed dogs. The disease can start with arrhythmias or with systolic dysfunction of the myocardium. OBJECTIVE To describe screening methods for DCM in various breeds and
G. Wess
semanticscholar +1 more source
Circulation: Arrhythmia and Electrophysiology, 2013 Neal K Lakdawala, Birgit Funke
exaly +3 more sources
The Lancet, 2010
Dilated cardiomyopathy is characterised by left ventricular dilation that is associated with systolic dysfunction. Diastolic dysfunction and impaired right ventricular function can develop. Affected individuals are at risk of left or right ventricular failure, or both. Heart failure symptoms can be exercise-induced or persistent at rest.
John Lynn, Jefferies, Jeffrey A, Towbin
openaire +2 more sources
Dilated cardiomyopathy is characterised by left ventricular dilation that is associated with systolic dysfunction. Diastolic dysfunction and impaired right ventricular function can develop. Affected individuals are at risk of left or right ventricular failure, or both. Heart failure symptoms can be exercise-induced or persistent at rest.
John Lynn, Jefferies, Jeffrey A, Towbin
openaire +2 more sources
Current Opinion in Cardiology, 1994
The etiology and pathogenesis of dilated cardiomyopathy continues to be controversial. The importance of viral and familial etiologies is becoming increasingly recognized. Molecular biology will add significantly to our understanding of these factors in the near future.
S C, Siu, M J, Sole
openaire +2 more sources
The etiology and pathogenesis of dilated cardiomyopathy continues to be controversial. The importance of viral and familial etiologies is becoming increasingly recognized. Molecular biology will add significantly to our understanding of these factors in the near future.
S C, Siu, M J, Sole
openaire +2 more sources
Immunoadsorption in dilated cardiomyopathy
Transfusion and Apheresis Science, 2007Dilated cardiomyopathy (DCM) is a common myocardial disease characterized by ventricular dilatation and progressive depression of myocardial contractile function. Disturbances in both humoral and cellular immunity have been described among these patients. A number of antibodies against various cardiac cell proteins have been identified in DCM.
Alexander, Staudt, Stephan B, Felix
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Alcoholic dilated cardiomyopathy
Nursing Standard, 2008This article provides an overview of alcoholic dilated cardiomyopathy. It aims to increase awareness of the condition among nurses, and help in early diagnosis and appropriate treatment referrals. The key message is that all patients with alcoholic dilated cardiomyopathy should be advised and assisted to stop drinking alcohol.
Anna, Adam +2 more
openaire +2 more sources