Results 41 to 50 of about 591,365 (304)

Integrated analysis reveals the dysfunction of intercellular communication and metabolic signals in dilated cardiomyopathy

Heliyon
Aims: Dilated cardiomyopathy refers to a heart muscle condition characterized by structural and functional irregularities in the myocardium that are not related to ischemia. Due to diverse etiologies such as genetic mutations, infections, and exposure to
Rui Shi, Xiue Ma, Mi Zhou, Xin Xie, Liang Xu   +4 more
doaj   +1 more source

Similar burden of rare genetic variants in ischemic and non-ischemic dilated cardiomyopathy

Frontiers in Cardiovascular Medicine
BackgroundThe aim of the study was to determine the prevalence of rare disease-causing variants in cardiomyopathy-associated genes in a cohort of patients with ischemic and non-ischemic dilated cardiomyopathy undergoing heart transplant.MethodsWe ...
Louie Cao, Joshua Rushakoff, Ian Williamson, Anja Karlstaedt, Michelle Kittleson, Lawrence Czer, Evan P. Kransdorf   +6 more
doaj   +1 more source

Activation of PDGF Pathway Links LMNA Mutation to Dilated Cardiomyopathy

Nature, 2019
Lamin A/C (LMNA) is one of the most frequently mutated genes associated with dilated cardiomyopathy (DCM). DCM related to mutations in LMNA is a common inherited cardiomyopathy that is associated with systolic dysfunction and cardiac arrhythmias. Here we
Jaecheol Lee, Vittavat Termglinchan, Sebastian Diecke, Ilanit Itzhaki, C. Lam, Priyanka Garg, E. Lau, Matthew Greenhaw, T. Seeger, Haodi Wu, Joe Z. Zhang, Xingqi Chen, I. P. Gil, Mohamed Ameen, Karim Sallam, J. Rhee, Jared M. Churko, Rinkal Chaudhary, Tony Chour, Paul Wang, M. Snyder, Howard Y. Chang, I. Karakikes, Joseph C. Wu   +23 more
semanticscholar   +1 more source

Dilated cardiomyopathy and arrhythmogenic left ventricular cardiomyopathy: a comprehensive genotype-imaging phenotype study.

European Heart Journal-Cardiovascular Imaging, 2019
AIMS Myocardial scar detected by cardiovascular magnetic resonance has been associated with sudden cardiac death in dilated cardiomyopathy (DCM). Certain genetic causes of DCM may cause a malignant arrhythmogenic phenotype. The concepts of arrhythmogenic
J. Augusto, R. Eiros, E. Nakou, Sara Moura-Ferreira, T. Treibel, G. Captur, M. Akhtar, A. Protonotarios, T. Gossios, K. Savvatis, P. Syrris, Saidi A Mohiddin, J. Moon, P. Elliott, L. Lopes   +14 more
semanticscholar   +1 more source

Prospective Evaluation of the Utility of Whole Exome Sequencing in Dilated Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Dilated cardiomyopathy may be heritable but shows extensive genetic heterogeneity. The utility of whole exome sequencing as a first‐line genetic test for patients with dilated cardiomyopathy in a contemporary “real‐world” setting has not been ...
Jay Ramchand, Mathew Wallis, Ivan Macciocca, Elly Lynch, Omar Farouque, Melissa Martyn, Dean Phelan, Belinda Chong, Siobhan Lockwood, Robert Weintraub, Tina Thompson, Alison Trainer, Dominica Zentner, Jitendra Vohra, Michael Chetrit, David L. Hare, Paul James   +16 more
doaj   +1 more source

Dilated cardiomyopathy: from epidemiologic to genetic phenotypes

Journal of Internal Medicine, 2019
Dilated cardiomyopathy (DCM) is characterized by left ventricular dilatation and, consecutively, contractile dysfunction. The causes of DCM are heterogeneous. DCM often results from myocarditis, exposure to alcohol, drugs or other toxins and metabolic or
D. Reichart, C. Magnussen, T. Zeller, S. Blankenberg   +3 more
semanticscholar   +1 more source

Gold Nanorods in Cardiac Millitissues: Assessing Mechanical and Contractile Dynamics in a Living Engineering Myocardium Model

Advanced Materials Technologies, EarlyView.
This study presents a novel platform for assessing the active mechanical behavior of living cardiac microbundles through localized nanoindentation, integrated with temperature regulation and dual‐camera imaging systems. The developed system enables quantitative evaluation of dynamic micromechanics in engineered cardiac tissues in vitro, offering ...
Lihua Lou, Lia Paolino, Alberto Sesena Rubfiaro, Jin He, Arvind Agarwal   +4 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Cardiomyopathy, familial dilated [PDF]

Orphanet Journal of Rare Diseases, 2006
AbstractDilated cardiomyopathy (DCM) is a heart muscle disease characterized by ventricular dilatation and impaired systolic function. Patients with DCM suffer from heart failure, arrhythmia, and are at risk of premature death. DCM has a prevalence of one case out of 2500 individuals with an incidence of 7/100,000/year (but may be under diagnosed).
Mestroni Luisa, Carniel Elisa, Taylor Matthew RG   +2 more
openaire   +3 more sources

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source