Results 71 to 80 of about 591,365 (304)
Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco +2 more
wiley +1 more source
Urology Case Reports, 2020 An 11-month-old boy with unilateral Wilms tumor had an unusual presentation, with dilated hypertensive cardiomyopathy, acute myocarditis, pulmonary edema, and congestive heart failure secondary to the Wilms tumor and requiring intensive care.
Jae Min Chung, Sang Don Lee
doaj +1 more source
Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy
Heart Failure Clinics, 2018 Synopsis Sarcomere cardiomyopathies are genetic diseases that perturb contractile function and lead to dilated or hypertrophic myocardial remodeling. Identification of preclinical mutation carriers has yielded insights into the earliest biomechanical ...
Amanda C Garfinkel +2 more
semanticscholar +1 more source
Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases
Animal Models and Experimental Medicine, EarlyView.Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam +4 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/fibroblast growth factor–inducible 14 (Fn14) signaling in SLE‐related ...
Yale Liu +12 more
wiley +1 more source
Sex and Age-Based Differences in the Natural History and Outcome of Dilated Cardiomyopathy
European Journal of Heart Failure, 2018 To evaluate the relationship between sex, age and outcome in dilated cardiomyopathy (DCM).
B. Halliday +18 more
semanticscholar +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Index of microcirculatory resistance (IMR) is a cutting‐edge, wire‐based tool that advances the capability assessment of coronary microvascular function. By utilizing distal coronary pressure and mean transit time under maximal hyperemia, IMR delivers consistent, reproducible insights into the microvasculature's dynamic health.
Joanna Sohn +10 more
wiley +1 more source
A case of dilated cardiomyopathy [PDF]
Rural and Remote Health, 2012 Dilated cardiomyopathy is a significant health problem in Africa. Diagnosis and treatment can be challenging as it frequently affects young patients and those without risk factors for cardiac disease.A previously well HIV negative 17 year old boy presented to Mseleni hospital in December 2011 with a short history of worsening shortness of breath on ...
J D, Binham, V, Fredlund
openaire +2 more sources
Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets
PLoS ONE, 2018 Introduction Golden retrievers are over-represented in cases of taurine-deficient dilated cardiomyopathy and recently a surge in cases has prompted further investigation.
J. Kaplan +22 more
semanticscholar +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background The EMPIRE I study assessed the early (30 days) safety and efficacy of a new fully repositionable delivery system (IMPERIA) for the commercially available ALLEGRA transcatheter aortic valve in patients with either severe native aortic stenosis or a degenerated surgical bioprosthesis.
José Antonio Baz +15 more
wiley +1 more source