Results 101 to 110 of about 46,771 (265)

Calpain inhibition in a transgenic model of calpastatin overexpression facilitates reversal of myocardial hypertrophy

ESC Heart Failure, EarlyView.
Abstract Aims It was recently demonstrated that the intracellular signalling phosphatase calcineurin is subject to cleavage by the protease calpain, resulting in a truncated calcineurin fragment that is a strong inductor of myocardial hypertrophy. We now address the question of whether inhibition of calpain function in cardiomyocytes, and thereby ...
Gregor Sachse, Johanna Tennigkeit, Nikolaos Pagonas, Philipp Hillmeister, Ivo Buschmann, Martin Czolbe, Peter Nordbeck, Joachim Schmitt, Daniel Patschan, Oliver Ritter   +9 more
wiley   +1 more source

Multi-Scale Fiber Remodeling in HCM Using a Stress-Based Fiber Reorientation Law [PDF]

arXiv
Quantifying fiber disarray, which is a prominent maladaptation associated with hypertrophic cardiomyopathy, remains critical to understanding the disease's complex pathophysiology. This study investigates the role of heterogeneous impairment of fiber contractility and fibrosis in the induction of disarray and their subsequent impact on cardiac pumping ...
arxiv  

Prognostic implications of functional tricuspid regurgitation in asymptomatic degenerative mitral regurgitation

ESC Heart Failure, EarlyView.
Abstract Aims Functional tricuspid regurgitation (FTR) associated with degenerative mitral regurgitation (DMR) accentuates the severity of heart failure and is a marker of poor prognosis. Little is known about FTR associated with asymptomatic DMR. Methods and results The study included 1249 asymptomatic patients with moderate or severe DMR from the ...
Christophe Tribouilloy, Yohann Bohbot, Benjamin Essayagh, Giovanni Benfari, Jeroen J. Bax, Thierry Le Tourneau, Yan Topilsky, Clemence Antoine, Dan Rusinaru, Francesco Grigioni, Nina Ajmone Marsan, Aniek van Wijngaarden, Aviram Hochstadt, Jean Christian Roussel, Prabin Thapa, Michelena Hector I, Maurice Enriquez‐Sarano   +16 more
wiley   +1 more source

Identification of a novel titin-cap/telethonin mutation in a Portuguese family with hypertrophic cardiomyopathy

Revista Portuguesa de Cardiologia, 2020
Introduction and objectives: Hypertrophic cardiomyopathy (HCM) is a genetically and phenotypically heterogeneous disease; there is still a large proportion of patients with no identified disease-causing mutation.
Alexandra Toste, Andreas Perrot, Cemil Özcelik, Nuno Cardim   +3 more
doaj  

Management of hypertrophic cardiomyopathy

Journal of Cardiovascular Medicine
Hypertrophic cardiomyopathy is an important cause of heart failure and arrhythmias, including sudden death, with a major impact on the healthcare system. Genetic causes and different phenotypes are now increasingly being identified for this condition.
Zhang, Yuhui, Adamo, Marianna, Zou, Changhong, Porcari, Aldostefano, Tomasoni, Daniela, Rossi, Maddalena, Merlo, Marco, Liu, Huihui, Wang, Jinxi, Zhou, Ping, Metra, Marco, Sinagra, Gianfranco, Zhang, Jian   +12 more
openaire   +4 more sources

Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction

ESC Heart Failure, EarlyView.
Abstract Aims Two general phenotypes of heart failure (HF) are recognized: HF with reduced ejection fraction (HFrEF) and with preserved EF (HFpEF). To develop phenotype‐specific approaches to treatment, distinguishing biomarkers are needed. The goal of this study was to utilize quantitative metabolomics on a large, diverse population to replicate and ...
Fawaz Naeem, Teresa C. Leone, Christopher Petucci, Clarissa Shoffler, Ravindra C. Kodihalli, Tiffany Hidalgo, Cheryl Tow‐Keogh, Jessica Mancuso, Iphigenia Tzameli, Donald Bennett, John D. Groarke, Rachel J. Roth Flach, Daniel J. Rader, Daniel P. Kelly   +13 more
wiley   +1 more source

Pharmacokinetics of a single dose of Aficamten (CK‐274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model

Journal of Veterinary Pharmacology and Therapeutics, Volume 46, Issue 1, Page 52-61, January 2023., 2023
Abstract Hypertrophic cardiomyopathy (HCM) is the most prevalent cardiac disease in cats and lacks efficacious preclinical pharmacologic intervention, prompting investigation of novel therapies. Genetic mutations encoding sarcomeric proteins are implicated in the development of HCM and small molecule myosin inhibitors are an emerging class of ...
Ashley N. Sharpe, Maureen S. Oldach, Joanna L. Kaplan, Victor Rivas, Samantha L. Kovacs, Darren T. Hwee, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern   +9 more
wiley   +1 more source

Multi-Stage Segmentation and Cascade Classification Methods for Improving Cardiac MRI Analysis [PDF]

arXiv
The segmentation and classification of cardiac magnetic resonance imaging are critical for diagnosing heart conditions, yet current approaches face challenges in accuracy and generalizability. In this study, we aim to further advance the segmentation and classification of cardiac magnetic resonance images by introducing a novel deep learning-based ...
arxiv  

Clinical characteristics and long‐term outcomes in patients with apical hypertrophic cardiomyopathy

ESC Heart Failure, EarlyView.
Abstract Aims As a special type of hypertrophic cardiomyopathy (HCM), apical HCM (ApHCM) has different clinical characteristics while its nature history and prognosis are not well recognized. We aimed to describe the characteristics and outcomes of ApHCM and identify predictors of adverse outcomes.
Meng Guo, Chuanfen Liu, Jingjing Ye, Jian Liu   +3 more
wiley   +1 more source

Surgical Treatment for Severe Cervical Hyperlordosis and Thoracolumar Kyphoscoliosis with Emery–Dreifuss Muscular Dystrophy: A Case Report and Literature Review

Orthopaedic Surgery, Volume 14, Issue 12, Page 3448-3454, December 2022., 2022
In patients with Emery–Dreifuss muscular dystrophy (EDMD), cervical deformity secondary to contractures of posterior cervical muscle in such patients should be corrected in the first stage considering its role as a “driver” of the global spine deformity.
Ziyang Tang, Zongshan Hu, Xiaodong Qin, Zezhang Zhu, Zhen Liu   +4 more
wiley   +1 more source