Results 111 to 120 of about 310,703 (307)

Exploring Raman Spectroscopy as a Detection Tool for Cardiovascular Diseases and Diabetes Mellitus in Fingernails

Journal of Raman Spectroscopy, EarlyView.
Endogenous constituents vary between fingernails of healthy, cardiovascular and diabetic participants. Raman spectroscopy yields a biochemical fingerprint of key endogenous constituents and disease‐related biomarkers. Combined with machine learning algorithms, Raman spectroscopy can classify healthy, cardiovascular and diabetic based on their Raman ...
Megan Wilson, Dhiya Al‐Jumeily, Leung Tang, Jason Birkett, Iftikhar Khan, Ismail Abbas, Matthew Harper, Sulaf Assi   +7 more
wiley   +1 more source

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure [PDF]

, 2019
Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from transplant center operating rooms, and ...
Ashley, Euan A., Bernstein, Daniel, Brandimarto, Jeff, Cappola, Thomas, Chang, Alex C., Chin, Elizabeth T., Connolly, Andrew, Cordero, Pablo, Depaoli-Roach, Anna A., Dewey, Frederick, Erbilgin, Ayca, Glazer, Nicole, Gloudemans, Michael J., Hakonarson, Hakon, Hannenhalli, Sridhar, Huang, Yong, Li, Hongzhe, Li, Mingyao, Lusis, Aldons J., Malloy, Christine, Margulies, Kenneth B., Montgomery, Stephen B., Moravec, Christine S., Morley, Michael, Parikh, Victoria N., Pavlovic, Aleksandra, Ritter, Scott, Shang, Ching, Skreen, Jamie, Smith, Kevin S., Tang, W. H. Wilson, Waggott, Daryl, Wheeler, Matthew T., Zaleta, Kathia, Zhao, Mingming   +34 more
core   +2 more sources

[2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy].

Kardiologia polska, 2014
© 2015, Silicea-Poligraf. All Rights Reserved. The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC).
Perry M. Elliott, A. Anastasakis, M. Borger, Martin Borggrefe, F. Cecchi, P. Charron, A. Hagège, A. Lafont, Giuseppe Limongelli, H. Mahrholdt, W. McKenna, J. Mogensen, P. Nihoyannopoulos, S. Nistri, P. Pieper, B. Pieske, C. Rapezzi, F. Rutten, Christoph Tillmanns, Hugh Watkins   +19 more
semanticscholar   +1 more source

Alogliptin Reduces Oxidative Stress in Cardiomyocytes and Ameliorates Diabetic Cardiomyopathy via the AURKB/NLGN2 Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus. This study investigated the effects of alogliptin on DCM and its underlying mechanisms. A DCM model was constructed and treated with alogliptin. Downstream targets of alogliptin were screened using bioinformatics analysis.
Li‐Jing Jiao, Jing Zhou, Jing Wang, Si‐Nan Zhao, Zhan‐Sheng Zhao, Qian Wang, Ya‐Nan Xie, Wei Jiao   +7 more
wiley   +1 more source

Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure [PDF]

, 2016
RATIONALE: In heart failure, myofilament proteins display abnormal phosphorylation, which contributes to contractile dysfunction. The mechanisms underlying the dysregulation of protein phosphorylation on myofilaments is not clear.
Barbagallo, Federica, Bers, Donald, Bossuyt, Julie, Ferrier, William, Fu, Qin, Ginsburg, Kenneth S., Isidori, Andrea, Li, Minghui, Naro, Fabio, Patel, Hemal H., Reddy, Gopireddy R., Shi, Qian, Wang, Qingtong, West, Toni, Xiang, Yang K., Xu, Bing   +15 more
core   +1 more source

Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy

Circulation, 2018
Background: A better understanding of the factors that contribute to heterogeneous outcomes and lifetime disease burden in hypertrophic cardiomyopathy (HCM) is critically needed to improve patient management and outcomes.
Carolyn Y. Ho, S. Day, E. Ashley, M. Michels, A. Pereira, D. Jacoby, Allison L. Cirino, J. Fox, N. Lakdawala, J. Ware, C. Caleshu, A. Helms, S. Colan, F. Girolami, F. Cecchi, C. Seidman, G. Sajeev, J. Signorovitch, Eric M. Green, I. Olivotto   +19 more
semanticscholar   +1 more source

Physical exercise and cardiac death due to pneumonia in male teenagers [Iznenadna smrt zbog upalće pluća za vrijeme tjelovježbe u trojice mladića] [PDF]

, 2009
From 1998 to 2008 we noticed 3 cardiac deaths in male teenagers aged 18-19 during or after physical exercise. The first was working at the site recreatively, the second was engaged in soccer recreatively and the third was professional soccer player.
Duraković, Lejla, Duraković, Zijad, Mišigoj Duraković, Marjeta, Škavić, Josip   +3 more
core  

Plasma Cardiac Troponin I Concentration and Cardiac Death in Cats with Hypertrophic Cardiomyopathy [PDF]

, 2014
BACKGROUND: The use of cardiac biomarkers to assist in the diagnosis of occult and symptomatic hypertrophic cardiomyopathy (HCM) in cats has been established. There is limited data describing their prognostic utility in cats with HCM.
Abbott, Atkins, Bang, Blume, Chan, Christiaans, Coats, Connolly, Connolly, Connolly, Fernandes, Fox, Fox, Fox, Gersh, Geske, Herndon, Humm, Kittleson, Kubo, Kubo, Langhorn, Lefbom, Lyons, Maron, Maron, Maron, Moreno, Ohno-Machado, Oyama, Paige, Payne, Payne, Peacock, Perna, Perna, Rush, Schober, Schober, Schober, Singletary, Trehiou-Sechi, Wagner, Wess   +43 more
core   +2 more sources

Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Pflügers Archiv: European Journal of Physiology, 2019
Several lines of evidence suggest that the primary effect of hypertrophic cardiomyopathy mutations in human β-cardiac myosin is hypercontractility of the heart, which leads to subsequent hypertrophy, fibrosis, and myofilament disarray.
J. Spudich
semanticscholar   +1 more source

Heart failure in two male patients with late‐onset Fabry mutation (IVS4 + 919G > A)

ESC Heart Failure, Volume 12, Issue 2, Page 1508-1513, April 2025.
Xufei Yang, Chunlan Deng, Xiaogang Guo, Hui Yan   +3 more
wiley   +1 more source