Results 131 to 140 of about 310,703 (307)

Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy.

Journal of the American College of Cardiology, 2022
M. Desai, A. Owens, J. Geske, K. Wolski, S. Naidu, N. Smedira, P. Cremer, H. Schaff, E. McErlean, Christina Sewell, Wanying Li, Lulu Sterling, K. Lampl, J. Edelberg, A. Sehnert, S. Nissen   +15 more
semanticscholar   +1 more source

2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC).

European Heart Journal, 2014
2D : two-dimensional 99mTc-DPD : 99mTechnetium-3,3-diphosphono- 1,2-propanodi-carboxylic acid ACE : angiotensin-converting enzyme AF : atrial fibrillation AL : amyloid light chain AR : aortic regurgitation ARB : angiotensin receptor blocker ATTR ...
Perry M. Elliott, A. Anastasakis, Michael A. Borger, M. Borggrefe, Franco Cecchi, Philippe Charron, A. Hagège, Antoine Lafont, G. Limongelli, H. Mahrholdt, William J. McKenna, Jens Mogensen, P. Nihoyannopoulos, Stefano Nistri, Petronella G. Pieper, Burkert Pieske, Claudio Rapezzi, Frans H. Rutten, Christoph Tillmanns, Hugh Watkins   +19 more
semanticscholar   +1 more source

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Gap junction reduction in cardiomyocytes following transforming growth factor- beta treatment and Trypanosoma cruzi infection [PDF]

, 2009
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta).
Becker, D, Burnstock, G, Coutinho-Silva, R, de Araujo-Jorge, TC, Feige, JJ, Higuchi, MD, Waghabi, MC   +6 more
core   +2 more sources

Management of Hypertrophic Cardiomyopathy: JACC State-of-the-Art Review.

Journal of the American College of Cardiology, 2022
B. Maron, M. Desai, R. Nishimura, P. Spirito, H. Rakowski, J. Towbin, J. Dearani, E. Rowin, M. Maron, M. Sherrid   +9 more
semanticscholar   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity

Nature Genetics, 2021
A. Harper, A. Goel, C. Grace, K. Thomson, Steffen Erhard Petersen, Xiao Xu, A. Waring, Elizabeth Ormondroyd, C. Kramer, Carolyn Y. Ho, S. Neubauer, Paul Raymond Sarahfaye F. Patrice John P. Nancy Dong-Yu Kolm Kwong Dolman Desvigne-Nickens Dimarco Geller , P. Kolm, Raymond Kwong, S. Dolman, P. Desvigne‐Nickens, J. Dimarco, Nancy Geller, Dong-Yun Kim, Cheng Zhang, W. Weintraub, T. Abraham, Lisa Anderson, E. Appelbaum, C. Autore, C. Berry, E. Biagini, W. Bradlow, C. Bucciarelli-Ducci, A. Chiribiri, L. Choudhury, A. Crean, D. Dawson, M. Desai, E. Elstein, A. Flett, Matthias Friedrich, S. Heitner, Adam Helms, Daniel L. Jacoby, Han Kim, Bette Kim, É. Larose, M. Mahmod, H. Mahrholdt, M. Maron, Gerry McCann, M. Michels, Saidi A Mohiddin, Sherif F. Nagueh, D. Newby, I. Olivotto, A. Owens, F. Pierre-Mongeon, S. Prasad, O. Rimoldi, M. Salerno, J. Schulz-Menger, M. Sherrid, P. Swoboda, A. van Rossum, J. Weinsaft, J. White, Eric Williamson, R. Tadros, J. Ware, C. Bezzina, M. Farrall, H. Watkins   +68 more
semanticscholar   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Enhancing explainability in clinical deep-learning models: Latent-space variable decoding is superior to gradient-weighted class activation mapping

Heart Rhythm O2
Background: Deep-learning models designed to assist with clinical decision making abound in cardiology. However, the “black box” nature of these models limits physicians’ ability to use them to cross-check clinical gestalt when evaluating model ...
Richard T. Carrick, MD, PhD, Ethan J. Rowin, MD, Alessio Gasperetti, MD, PhD, Christopher Madias, MD, Martin Maron, MD, Katherine C. Wu, MD   +5 more
doaj   +1 more source

Hypertrophic cardiomyopathy: genetics and clinical perspectives.

Cardiovascular Diagnosis and Therapy, 2019
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and defined by unexplained isolated progressive myocardial hypertrophy, systolic and diastolic ventricular dysfunction, arrhythmias, sudden cardiac death and histopathologic ...
C. Wolf
semanticscholar   +1 more source