Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.Cardiac bioenergetic and metabolic perturbations in late‐stage Leigh syndrome. Whole‐body NDUFS4 loss severely impairs cardiac complex I activity and respiration, shifting reliance to complex II and reducing glycolytic, TCA, and amino acid‐derived energy‐generating substrates in the heart.
Karin Terburgh +2 more
wiley +1 more source
Erratum: Integrative bioinformatics approach for identifying key genes and potential therapeutic targets in the concurrent manifestation of hypertrophic cardiomyopathy and pulmonary hypertension. [PDF]
J Thorac DisEditorial Office.
europepmc +1 more source
JIMD Reports, Volume 67, Issue 1, January 2026.ABSTRACT The objective of this study is to evaluate whether early enzyme replacement therapy (ERT) initiation is associated with a lower incidence of echocardiogram abnormalities and cardiac conduction abnormalities compared to later ERT initiation.
Jennifer L. Cohen +6 more
wiley +1 more source
Mavacamten in hypertrophic obstructive cardiomyopathy with hepato-renal comorbidities: A case report. [PDF]
Medicine (Baltimore)Ma L, Li F, Dong S, Li R.
europepmc +1 more source
JIMD Reports, Volume 67, Issue 1, January 2026.ABSTRACT Methylmalonic acidemia (MMA) is a rare metabolic disorder with various subtypes, including Cobalamin B (cblB) disease. While cardiac complications are well‐documented in propionic acidemia, their occurrence in MMA is less understood. Here, we report a 12‐year‐old child with cblB disorder who developed acute cardiomyopathy (CM).
Dalia Said, Aisha Al Shamsi
wiley +1 more source
Novel characterization of MRAS mutation-associated Noonan syndrome: Mild adult-onset hypertrophic cardiomyopathy combined with infective endocarditis: A case report. [PDF]
Medicine (Baltimore)Mou X, Liu Y, Zhang Y, Cheng X, Feng J.
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4D Flow MRI Velocity and Turbulence Mapping in Mild Valvular Heart Disease
Journal of Magnetic Resonance Imaging, Volume 63, Issue 1, Page 222-232, January 2026.ABSTRACT Background Valvular heart disease (VHD) commonly leads to the development of turbulent blood flow. Turbulent kinetic energy (TKE), measured with 4D flow MRI, may be a complement to current metrics for early identification of VHD. Purpose To investigate TKE as a marker of VHD in relation to flow velocity and cardiovascular geometry.
Tamara Bianchessi +7 more
wiley +1 more source
Subendocardial Late Gadolinium Enhancement Without Troponin Elevation: A Case of Apical Hypertrophic Cardiomyopathy With Myocardial Involvement. [PDF]
CureusMartinez Juarez D +3 more
europepmc +1 more source
Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions
MedComm, Volume 7, Issue 1, January 2026.The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin +3 more
wiley +1 more source
The value of cardiac magnetic resonance delayed enhancement combined with tissue tracking in discriminating cardiac amyloidosis from hypertrophic cardiomyopathy. [PDF]
Front Cardiovasc MedXue XG, Xu XY, Lin XY, Wang GY, Dong HB.
europepmc +1 more source