Results 151 to 160 of about 104,815 (291)

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Uncovering hypertrophic cardiomyopathy pathophysiology – the unsolved role of microvascular dysfunction

Revista Portuguesa de Cardiologia, 2022
Alexandra Toste
doaj   +1 more source

Case Report: Mavacamten in mid-ventricular and apical hypertrophic cardiomyopathy-a case of targeted therapy beyond left ventricular outflow tract obstruction. [PDF]

Front Med (Lausanne)
Yang L, Dai H, Rong Y.
europepmc   +1 more source

Haemodynamic‐energetic mechanism of sudden cardiac death in severe aortic stenosis: A modelling study

The Journal of Physiology, EarlyView.
Abstract figure legend A sudden decrease in total peripheral resistance (TPR), as observed during vasovagal syncope, leads to a reduction in aortic systolic pressure (AO pressure) and afterload. In healthy individuals, the consequent decrease in left ventricular systolic pressure (LV pressure) lowers stroke work and myocardial energy expenditure.
Martin Dvoulety, Michal Sitina
wiley   +1 more source

Cardiac Myosin Inhibitors as a Novel Treatment Option for Obstructive Hypertrophic Cardiomyopathy: Addressing the Core of the Matter

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Ahmad Masri, Iacopo Olivotto
doaj   +1 more source

What Do We Know About Hypertrophic Cardiomyopathy in Poland in the Period 2016-2021 Based on Data From the Public Health System? [PDF]

Int J Public Health
Niemiec M, Stec M, Grzybowski J, Cegłowska U, Wiśniewska A, Hałgas K, Czepczor K, Podolski M, Gruchlik B, Orzeł-Łomozik G, Cieśla D, Gąsior M, Hryniewiecki T, Leszek P, Caforio ALP, Mizia-Stec K.   +15 more
europepmc   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Hypertrophic Cardiomyopathy as a Key Feature of MRAS-Related Noonan Syndrome: New Case and Comprehensive Literature Review. [PDF]

Prenat Diagn
Martineau R, Wells C, Fuchs F, Collardeau-Frachon S, Ruault V, Colomb S, Faure JM, Bartholmot C, Vincenti M, Ganne B, Willems M.   +10 more
europepmc   +1 more source