Results 151 to 160 of about 117,203 (208)

The three‐element Windkessel parameters have empirical relations that uniquely define the mechanoenergetics of cardiac muscle shortening

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend By collecting literature data across multiple species, we identified empirical relations among arterial resistance, compliance and impedance, which are the three biophysical indices used to characterise the arterial load against which the heart ejects.
Chamal Kohombakadawala   +4 more
wiley   +1 more source

Astragaloside IV and Ferroptosis Modulation in Pathological Cardiac Hypertrophy: Current Evidence, an Integrative Hypothesis, and Future Directions

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT Pathological cardiac hypertrophy is initially an adaptive response to sustained mechanical, neurohormonal, or metabolic stress; however, it can progress to fibrosis, contractile dysfunction, arrhythmia, and heart failure. Ferroptosis is a type of regulated cell death caused by iron‐dependent phospholipid peroxidation.
Pengbo Liu, Yongzhi Deng
wiley   +1 more source

Acute Angina in Anomalous Left Main Coronary Artery With Prepulmonic Course: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Although a prepulmonic left main coronary artery is usually considered a lower‐risk AAOCA subtype, it may still be associated with acute ischemic symptoms when significant atherosclerotic coronary artery disease is present. Multimodality imaging is essential for defining the coronary anatomy, and coronary artery bypass grafting may be the ...
Mohammad Rouzbahani   +4 more
wiley   +1 more source

Circular RNAs in Drug‐Induced Cardiotoxicity: Roles, Mechanisms, and Therapeutic Potential

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Circular RNAs have emerged as novel regulators and potential biomarkers in drug‐induced cardiotoxicity. This review summarizes the biogenesis, functional roles, and translational potential of circRNAs in cardiotoxicity assessment and drug safety evaluation.
KeXin Leng   +5 more
wiley   +1 more source

Tailored Amino Acid Treatment for Pediatric Patients With Mitochondrial Aminoacyl‐tRNA Synthetase Deficiencies

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Aminoacyl‐tRNA synthetases (ARSs) facilitate the loading of transfer RNAs with their cognate amino acids in the cytosol (ARS1), mitochondria (ARS2), or both (dual ARS). ARS deficiencies are clinically heterogeneous and can cause severe, occasionally fatal disease.
I. J. J. Muffels   +21 more
wiley   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

open access: yesMedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He   +4 more
wiley   +1 more source

Genetic Insights Into Cardiomyopathy With Restrictive Phenotype: Implications for Diagnosis and Personalized Care

open access: yesMolecular Genetics &Genomic Medicine, Volume 14, Issue 11, November 2026.
Among 568 patients with cardiomyopathy, 33 exhibited a restrictive phenotype, including 7 with RCM, 20 with HRCM, and 6 with HDRCM. Pathogenic or likely pathogenic variants were identified in 24 patients (72.7%). Variant carriers had a smaller aortic sinus diameter than non‐carriers (30.79 ± 3.48 vs.
Nianwei Zhou   +11 more
wiley   +1 more source

Chronic, neutrophilic pericarditis with free‐floating intrapericardial mesothelial‐lined fibrous nodules in a cat

open access: yesVeterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 15‐year‐2‐month‐old, male, neutered domestic shorthair cat was presented for a 1‐week history of increased respiratory effort and declining appetite. Point‐of‐care ultrasound diagnosed tri‐cavitary effusion, and echocardiography revealed the presence of multiple free‐floating hyperechoic nodules within the pericardium.
Maximiliane Gabriele Sehn   +4 more
wiley   +1 more source

Understanding the Mortality Trends in Patients With Ventricular Arrhythmias and Cardiomyopathy: A 25‐Year Retrospective Analysis From 1999–2024

open access: yesAnnals of Noninvasive Electrocardiology, Volume 31, Issue 6, November 2026.
Central illustration depicting trends in demographics and differences in Ventricular Arrhythmias with Cardiomyopathy‐related Mortality among adults in the United States from 1999 to 2024. ABSTRACT Background Ventricular Arrhythmias (VA) associated with Cardiomyopathy (CM) continues to be the major cause of death.
Nosheen Pervaiz   +8 more
wiley   +1 more source

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