Results 51 to 60 of about 47,050 (167)

The genetics of hypertrophic cardiomyopathy

Global Cardiology Science and Practice, 2018
Hypertrophic cardiomyopathy (HCM) is most commonly transmitted as an autosomal dominant trait, caused by mutations in genes encoding cardiac sarcomere proteins. Other inheritable causes of the disease include mutations in genes coding for proteins important in calcium handling or that form part of the cytoskeleton. At present, the primary clinical role
Akhtar, M, Elliott, P
openaire   +5 more sources

CARDIOMYOPATHY: The diagnosis of hypertrophic cardiomyopathy [PDF]

Heart, 2001
Although the pathology of hypertrophic cardiomyopathy (HCM) was first described by French pathologists in the mid 19th century, it remained for the virtually simultaneous reports of Brock and Teare in England some 43 years ago to bring modern attention to this fascinating entity.1 2 Subsequent to these surgical1 and pathological2 observations, there ...
openaire   +3 more sources

Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis

Journal of Nanobiotechnology
Background Cardiac fibrosis plays a critical role in the progression of various forms of heart disease, significantly increasing the risk of sudden cardiac death.
Xueli Zhao, Yuze Qin, Bowen Li, Yue Wang, Jiao Liu, Bo Wang, Jia Zhao, Jiaqi Yin, Lanlan Zhang, Jing Li, Junzhe Huang, Kun Chen, Liwen Liu, Yuanming Wu   +13 more
doaj   +1 more source

Automatic Segmentation and Disease Classification Using Cardiac Cine MR Images [PDF]

arXiv, 2017
Segmentation of the heart in cardiac cine MR is clinically used to quantify cardiac function. We propose a fully automatic method for segmentation and disease classification using cardiac cine MR images. A convolutional neural network (CNN) was designed to simultaneously segment the left ventricle (LV), right ventricle (RV) and myocardium in end ...
arxiv  

HYPERTROPHIC CARDIOMYOPATHY: GENETIC ALTERATIONS, PATHOGENESIS AND PATHOPHYSIOLOGY

Российский кардиологический журнал, 2014
The review is dedicated to the description of genetic alterations, pathogenetic mechanisms and pathophysiology of hypertrophic cardiomyopathy, based on the analysis of current up to date information.
N. T. Vatutin, G. G. Taradin, M. S. Maron   +2 more
doaj   +1 more source

Computational analysis of folding and mutation properties of C5 domain from Myosin binding protein C [PDF]

arXiv, 2007
Thermal folding Molecular Dynamics simulations of the domain C5 from Myosin Binding Protein C were performed using a native-centric model to study the role of three mutations related to Familial Hypertrophic Cardiomyopathy. Mutation of Asn755 causes the largest shift of the folding temperature, and the residue is located in the CFGA' beta-sheet ...
arxiv  

Feature Tracking Cardiac Magnetic Resonance via Deep Learning and Spline Optimization [PDF]

arXiv, 2017
Feature tracking Cardiac Magnetic Resonance (CMR) has recently emerged as an area of interest for quantification of regional cardiac function from balanced, steady state free precession (SSFP) cine sequences. However, currently available techniques lack full automation, limiting reproducibility.
arxiv  

Diffuse interstitial fibrosis assessed by cardiac magnetic resonance is associated with dispersion of ventricular repolarization in patients with hypertrophic cardiomyopathy

Journal of Arrhythmia, 2017
Background: Hypertrophic cardiomyopathy (HCM) is characterized by myocyte hypertrophy, disarray, fibrosis, and increased risk for ventricular arrhythmias.
David Hurtado-de-Mendoza, MD, Celia P. Corona-Villalobos, MD, Iraklis Pozios, MD, Jorge Gonzales, MD, Yalda Soleimanifard, MD, Sanjay Sivalokanathan, MD, Diego Montoya-Cerrillo, MD, Styliani Vakrou, MD, Ihab Kamel, MD, Wilfredo Mormontoy-Laurel, MD, Ketty Dolores-Cerna, MD, Jacsel Suarez, MD, Sergio Perez-Melo, MD, David A. Bluemke, MD, Theodore P. Abraham, MD, Stefan L. Zimmerman, MD, M. Roselle Abraham, MD   +16 more
doaj   +1 more source

Hypertrophic cardiomyopathy [PDF]

Current Problems in Cardiology, 1993
Maron, B J, McKenna, W J, Elliott, P, Spirito, P, Frenneaux, M P, Keren, A, Cecchi, F, Borggrefe, M, Williams, W G   +8 more
openaire   +7 more sources

Is Hypertrophic Cardiomyopathy Always a Familial and Inherited Disease?

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Jiri Bonaventura, Ethan J. Rowin, Martin S. Maron, Barry J. Maron   +3 more
doaj   +1 more source