Results 191 to 200 of about 27,486 (234)

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Clinical application of cardiac computed tomography in cardiomyopathy. [PDF]

Int J Cardiovasc Imaging
Cau R, Gatti M, Suri JS, D'Angelo T, Saba L.   +4 more
europepmc   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Constrictive-effusive pericarditis and epicarditis as a cause of restrictive cardiomyopathy associated with Dirofilaria repens infection in a dog. [PDF]

BMC Vet Res
Szaluś-Jordanow O, Łobaczewski A, Jańczak D, Masny A, Kliczkowska K, Sapierzyński R, Zdeb K, Biernacka K, Gołąb E, Frymus T.   +9 more
europepmc   +1 more source

GLP‐1RA use improves outcomes post partial nephrectomy in T2DM patients with RCC: A TriNetX study

BJUI Compass, Volume 7, Issue 2, February 2026.
Abstract Objectives The purpose of this study is to investigate the impact of Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) use on 90‐day postoperative outcomes and overall survival following partial nephrectomy (PN) for renal cell carcinoma (RCC), where type 2 diabetes mellitus (T2DM) is a common comorbidity.
Sam Kwon, Fiona Wardrop, Diego Gonzalez, Francis Ryan, Liza Khutsishvili, Rollins Turner, Mohammad Ghassab Deameh, Michael J. Whalen   +7 more
wiley   +1 more source

Galectina-3 na Pericardite Constritiva Crônica: Informações Precisas para o Bom Médico

Arquivos Brasileiros de Cardiologia
Wolney de Andrade Martins
doaj   +1 more source

What Should a Clinical Cardiologist Know About Cardiogenetics? [PDF]

J Am Heart Assoc
Faggiano A, Calcagnino MM, Merlo M, Dal Ferro M, Moda F, Sanfilippo M, Garau L, Giordano C, Paldino A, Gigli M, Paganini S, Castronovo P, Ruscica M, Finelli P, Sinagra G, Carugo S.   +15 more
europepmc   +1 more source

Endomyocardial Fibrosis Associated With Hypereosinophilic Syndrome: Diagnostic and Management Insights From a Case Report

Catheterization and Cardiovascular Interventions, Volume 107, Issue 2, Page 520-523, February 1, 2026.
ABSTRACT Endomyocardial fibrosis (EMF) is a rare form of restrictive cardiomyopathy associated with eosinophilic disorders, characterized by apical subendocardial fibrosis and thrombus formation. Cardiac magnetic resonance (CMR) provides a comprehensive, noninvasive evaluation, enabling diagnosis, assessment of disease activity, and guidance of therapy.
Ibrahim Antoun, Benjamin Marrow, Ravi Pathmanathan, Sanjay S. Bhandari   +3 more
wiley   +1 more source

Identification of a Novel <i>FLNC</i> Truncating Variant in Fetal Tetralogy of Fallot: A Case Report and Review of the Literature. [PDF]

Diagnostics (Basel)
Zhang Z, Wang D, Fang C, Xu L, He S, Ren Z, Jia L, Liang X.   +7 more
europepmc   +1 more source

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source