Results 1 to 10 of about 352,654 (153)
Restrictive cardiomyopathy: from genetics and clinical overview to animal modeling
Reviews in Cardiovascular Medicine, 2022 Restrictive cardiomyopathy (RCM), a potentially devastating heart muscle disorder, is characterized by diastolic dysfunction due to abnormal muscle relaxation and myocardial stiffness resulting in restrictive filling of the ventricles.
Enkhsaikhan Purevjav
exaly +4 more sources
Restrictive cardiomyopathy: definition and diagnosis [PDF]
European Heart Journal, 2022 Restrictive cardiomyopathy (RCM) is a heterogeneous group of diseases characterized by restrictive left ventricular pathophysiology, i.e. a rapid rise in ventricular pressure with only small increases in filling volume due to increased myocardial ...
Andrea Barison, Alberto Aimo
exaly +3 more sources
Genetic Restrictive Cardiomyopathy: Causes and Consequences—An Integrative Approach
International Journal of Molecular Sciences, 2021 The sarcomere as the smallest contractile unit is prone to alterations in its functional, structural and associated proteins. Sarcomeric dysfunction leads to heart failure or cardiomyopathies like hypertrophic (HCM) or restrictive cardiomyopathy (RCM ...
Diana Cimiotti +2 more
exaly +2 more sources
Genetic Insights into Primary Restrictive Cardiomyopathy
Journal of Clinical Medicine, 2022 Restrictive cardiomyopathy is a rare cardiac disease causing severe diastolic dysfunction, ventricular stiffness and dilated atria. In consequence, it induces heart failure often with preserved ejection fraction and is associated with a high mortality ...
Andreas Brodehl, Brenda Gerull
exaly +2 more sources
Journal of Clinical Medicine, 2021 Hypertrophic cardiomyopathy (HCM) and primary restrictive cardiomyopathy (RCM) have a similar genetic background as they are both caused mainly by variants in sarcomeric genes.
Alberto Cipriani, Cristina Basso
exaly +2 more sources
Clinical Outcomes and Genetic Analyses of Restrictive Cardiomyopathy in Children
Circulation Genomic and Precision Medicine, 2023 BACKGROUND: Restrictive cardiomyopathy in children is rare and outcomes are very poor. However, little information is available concerning genotype-outcome correlations.
Kogaki Shigetoyo, Hidekazu Ishida
exaly +2 more sources
Focus on Paediatric Restrictive Cardiomyopathy: Frequently Asked Questions [PDF]
Diagnostics, 2023 Restrictive cardiomyopathy (RCM) is characterized by restrictive ventricular pathophysiology determined by increased myocardial stiffness. While suspicion of RCM is initially raised by clinical evaluation and supported by electrocardiographic and ...
Mattia Zampieri +16 more
doaj +2 more sources
Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy
Circulation: Cardiovascular Genetics, 2017 Background— Restrictive cardiomyopathy (RCM) is a rare cardiomyopathy characterized by impaired diastolic ventricular function resulting in a poor clinical prognosis.
Mark Lindsay +2 more
exaly +2 more sources
Case Report: Filamin C gene mutation associated with restrictive cardiomyopathy leading to heart transplantation [PDF]
Frontiers in TransplantationBackgroundCardiomyopathy is a disease that affects the myocardium and can be classified as dilated, restrictive, or hypertrophic cardiomyopathy. Among the subtypes, restrictive cardiomyopathy is characterized by restriction of ventricular filling and its
Ludmila De Oliveira Jaime Sales +4 more
doaj +2 more sources
Pediatric restrictive cardiomyopathy: a case report [PDF]
Journal of International Medical Research, 2023 Restrictive cardiomyopathy (RCM) is a rare childhood cardiomyopathy that is a challenging diagnostic problem for clinicians. We describe a case of an 8-year-old girl with a 2-year history of shortness of breath on exertion.
Hai-Long Dai +4 more
doaj +2 more sources