Results 131 to 140 of about 607,470 (403)

The challenge of cardiomyopathy

Journal of the American College of Cardiology, 1989
The combined clinical and pathophysiologic characteristics and diagnostic features as well as current concepts of pathogenesis, therapy and prevention of the principal forms of cardiomyopathy are reviewed. These include hypertrophic cardiomyopathy, dilated cardiomyopathy, restrictive cardiomyopathy and specific cardiac muscle disease.
Walter H. Abelmann, Beverly H. Lorell
openaire   +3 more sources

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Sudden Death and Left Ventricular Involvement in Arrhythmogenic Cardiomyopathy [PDF]

, 2019
BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized by myocardial fibrofatty replacement and an increased risk of sudden cardiac death (SCD).
Asimaki, A, Basu, J, Behr, ER, Cook, SA, Ensam, B, Finocchiaro, G, Gray, B, Malhotra, A, Miles, C, Papadakis, M, Papatheodorou, E, Parry-Williams, G, Paterson, C, Robertus, JL, Sharma, S, Sheppard, MN, Ster, IC, Tome, M, Ware, JS, Westaby, J, Witney, A   +20 more
core   +1 more source

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, Volume 12, Issue 28, July 24, 2025.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source

Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples

Genetics in Medicine, 2016
Purpose:The accurate interpretation of variation in Mendelian disease genes has lagged behind data generation as sequencing has become increasingly accessible.
R. Walsh, K. Thomson, J. Ware, B. Funke, Jessica Woodley, K. McGuire, F. Mazzarotto, E. Blair, A. Seller, Jenny C. Taylor, E. Minikel, D. MacArthur, M. Farrall, S. Cook, H. Watkins   +14 more
semanticscholar   +1 more source

Efficacy and safety of tafamidis doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR‐ACT) and long‐term extension study

European Journal of Heart Failure, 2020
Tafamidis is an effective treatment for transthyretin amyloid cardiomyopathy (ATTR‐CM) in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR‐ACT).
T. Damy, P. García-Pavía, M. Hanna, D. Judge, G. Merlini, B. Gundapaneni, T. Patterson, S. Riley, J. Schwartz, M. Sultan, R. Witteles   +10 more
semanticscholar   +1 more source

Cytokine Production but Lack of Proliferation in Peripheral Blood Mononuclear Cells from Chronic Chagas' Disease Cardiomyopathy Patients in Response to T. cruzi Ribosomal P Proteins [PDF]

, 2014
Background:Trypanosoma cruzi ribosomal P proteins, P2β and P0, induce high levels of antibodies in patients with chronic Chagas' disease Cardiomyopathy (CCC).
A Moncayo, A Rassi Jr, AC Arnholdt, Alcinette Buying, ARL Teixeira, AS de Melo, Augusto Atienza, B Zingales, C Aznar, C Chen, C Junqueira, C Smulski, Carlos A. Buscaglia, Clemencia Pinilla, CR De Marchi, E Cunha-Neto, E Mahler, E Mahler, E Olivares Fontt, E Olivares Fontt, E Roffê, EA Mesri, EB Gomez, F Kierszenbaum, F Nagajyothi, GE Cánepa, Graciela Perez Prados, GV Levy, I Ferrari, J Scharfstein, J Zhu, JA Fiuza, JAS Gomes, JC Coura, JM Burgos, JM Di Noia, JR Coura, K Elkon, Karina A. Gómez, KM Bonney, Laura M. Tasso, LC Abel, M Juri Ayub, M Ribeirao, MA Zacks, Mauricio Martins Rodrigues, MB Rosenbaum, MJ Morato, MV Elizari, NA Giraldo, P Lopez Bergami, P Lopez-Bergami, PA Chiale, Pablo Chiale, Radleigh Santos, RCG Fares, Ricardo Bonato, S Brandariz, S de Barros-Mazon, S Muller, Silvia A. Longhi, SL Topalian, V Judkowski, V Michailowsky, V Schultena, Valeria A. Judkowski, Virginia Balouz, VMB Lorena, WO Dutra, WO Dutra, WO Dutra, WO Dutra, WR Cuna, Y Belkaid, Y Morán-Utrera, Y Shi   +75 more
core   +4 more sources

Arrhythmogenic cardiomyopathy

Orphanet Journal of Rare Diseases, 2016
Arrhythmogenic cardiomyopathy (AC) is a heart muscle disease clinically characterized by life-threatening ventricular arrhythmias and pathologically by an acquired and progressive dystrophy of the ventricular myocardium with fibro-fatty replacement. Due to an estimated prevalence of 1:2000-1:5000, AC is listed among rare diseases. A familial background
PILICHOU, KALLIOPI, THIENE, GAETANO, BAUCE, BARBARA, Rigato, Ilaria, Lazzarini, Elisabetta, MIGLIORE, FEDERICO, PERAZZOLO MARRA, MARTINA, Rizzo, Stefania, Zorzi, Alessandro, DALIENTO, LUCIANO, CORRADO, DOMENICO, BASSO, CRISTINA   +11 more
openaire   +3 more sources

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Two Hearts at Risk

JACC: Case Reports, 2020
Hypertrophic obstructive cardiomyopathy (HOCM) increases the risk for mother and fetus during pregnancy. Alcohol septal ablation (ASA) is an established procedure in nonpregnant patients with HOCM. In this report, we present a case of a 29-year-old woman
Weng-Tein Gi, MD, MSc, Ali Amr, MD, Farbod Sedaghat-Hamedani, MD, Elham Kayvanpour, MD, Isabell Mohr, BSc, Manuela Meder, MD, Omid Shirvani Samani, MD, Herbert Fluhr, MD, Hugo A. Katus, MD, Benjamin Meder, MD   +9 more
doaj