Results 51 to 60 of about 441,361 (298)

Real‐World Observations in Patients With Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Evidence of Favorable Disease Modification

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Mavacamten is commercially approved for use in symptomatic patients with obstructive hypertrophic cardiomyopathy. This study evaluated its real‐world impact on symptoms, echocardiographic changes, and the need for septal reduction therapy in ...
Milind Y. Desai, Andrew Gaballa, Yuichiro Okushi, Mohammed Abusafia, Shada Jadam, Katy Rutkowski, Susan Ospina, Sanaa Sultana, Maran Thamilarasan, Craig Asher, Zoran B. Popovic, Bo Xu   +11 more
doaj   +1 more source

Syndrome of Reversible Cardiogenic Shock and Left Ventricular Ballooning in Obstructive Hypertrophic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Cardiogenic shock from most causes has unfavorable prognosis. Hypertrophic cardiomyopathy (HCM) can uncommonly present with apical ballooning and shock in association with sudden development of severe and unrelenting left ventricular (LV ...
Mark V. Sherrid, Daniel G. Swistel, Iacopo Olivotto, Maurizio Pieroni, Omar Wever‐Pinzon, Katherine Riedy, Richard G. Bach, Mustafa Husaini, Sharon Cresci, Alex Reyentovich, Daniele Massera, Martin S. Maron, Barry J. Maron, Bette Kim   +13 more
doaj   +1 more source

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy

Circulation Research, 2019
Rationale: Diabetic patients develop cardiomyopathy characterized by hypertrophy, diastolic dysfunction, and intracellular lipid accumulation, termed lipotoxicity.
Mingming Tong, Toshiro Saito, P. Zhai, S. Oka, Wataru Mizushima, Michinari Nakamura, Shohei Ikeda, A. Shirakabe, J. Sadoshima   +8 more
semanticscholar   +1 more source

Incidence of Stress Cardiomyopathy During the Coronavirus Disease 2019 Pandemic

JAMA Network Open, 2020
Key Points Question Is psychological, social, and economic stress associated with coronavirus disease 2019 (COVID-19) associated with the incidence of stress cardiomyopathy?
Ahmad Jabri, A. Kalra, Ashish Kumar, A. Alameh, S. Adroja, H. Bashir, A. Nowacki, R. Shah, Shameer Khubber, Anmar Kanaa’n, David P. Hedrick, Khaled M. Sleik, N. Mehta, M. Chung, U. Khot, S. Kapadia, R. Puri, G. Reed   +17 more
semanticscholar   +1 more source

Advances in Conductive Nanomaterials for Cardiac Arrhythmia and Future Directions in Bioevaluation Strategies

Advanced Healthcare Materials, EarlyView.
Conductive nanomaterials (CNMs) show promising potential in cardiac tissue regeneration and restoring cardiac rhythm as reported in several in vitro studies. This review article elaborates on the applications of CNMs in the treatment of myocardial infarction (MI) and MI‐induced cardiac arrhythmias, and it sheds light on the innovative approach of ...
Sumithra Y. Srinivasan, Anna Laromaine
wiley   +1 more source

Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2020
Diabetic cardiomyopathy is a result of diabetes-induced changes in the structure and function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but excessive reactive oxygen species (ROS) generation and oxidative stress ...
N. Kaludercic, F. Di Lisa
semanticscholar   +1 more source

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

Advanced Science, EarlyView.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source

AKT-mTOR signaling-mediated rescue of PRKAG2 R302Q mutant-induced familial hypertrophic cardiomyopathy by treatment with β-adrenergic receptor (β-AR) blocker metoprolol [PDF]

, 2022
Jian Zhuo, Hai-Hua Geng, Xiaohui Wu, Mengkang Fan, Hongzhuan Sheng, Jian Yao   +5 more
openalex   +1 more source

Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy

Circulation, 2018
Background: A better understanding of the factors that contribute to heterogeneous outcomes and lifetime disease burden in hypertrophic cardiomyopathy (HCM) is critically needed to improve patient management and outcomes.
Carolyn Y. Ho, S. Day, E. Ashley, M. Michels, A. Pereira, D. Jacoby, Allison L. Cirino, J. Fox, N. Lakdawala, J. Ware, C. Caleshu, A. Helms, S. Colan, F. Girolami, F. Cecchi, C. Seidman, G. Sajeev, J. Signorovitch, Eric M. Green, I. Olivotto   +19 more
semanticscholar   +1 more source

Early-Onset Atrial Fibrillation and the Prevalence of Rare Variants in Cardiomyopathy and Arrhythmia Genes

JAMA cardiology, 2021
Key Points Question In patients diagnosed with atrial fibrillation before 66 years of age, what is the prevalence of disease-associated variants in susceptibility genes for inherited cardiomyopathy and arrhythmia syndromes? Findings In this cohort study,
Z. Yoneda, K. Anderson, Joseph A. Quintana, M. O’Neill, Richard A. Sims, A. Glazer, C. Shaffer, Diane M. Crawford, T. Stricker, Fei Ye, Q. Wells, L. Stevenson, G. Michaud, D. Darbar, S. Lubitz, P. Ellinor, D. Roden, M. B. Shoemaker   +17 more
semanticscholar   +1 more source