The isolated, perfused working heart preparation of the mouse—Advantages and pitfalls
Acta Physiologica, Volume 241, Issue 4, April 2025.Abstract Isolated, perfused hearts are viable for hours outside the body, and important research findings have been made using mouse hearts ex vivo. In the Langendorff perfusion mode, the coronary tree is perfused via retrograde flow of a perfusate down the ascending aorta.
Diana S. Usai +2 more
wiley +1 more source
Canonical or non‐canonical, all aspects of G protein‐coupled receptor kinase 2 in heart failure
Acta Physiologica, Volume 241, Issue 3, March 2025.Abstract G protein‐coupled receptor kinase 2 (GRK2) with its multidomain structure performs various crucial cellular functions under both normal and pathological conditions. Overexpression of GRK2 is linked to cardiovascular diseases, and its inhibition or deletion has been shown to be protective.
Abdullah Kaplan +5 more
wiley +1 more source
Eniluracil blocks AREG signalling‐induced pro‐inflammatory fibroblasts of melanoma in heart failure
ESC Heart Failure, Volume 12, Issue 1, Page 525-541, February 2025.Abstract Aims Heart failure (HF) is characterized by a heightened risk of melanoma, which often metastasizes to the heart. The overlap pathology between HF and melanoma includes chronic low‐grade inflammation and dysregulation of inflammatory cancer‐associated fibroblasts (iCAFs).
Qin Ran, Long Chen
wiley +1 more source
Recovery of donor hearts after circulatory death with normothermic extracorporeal machine perfusion [PDF]
, 2017 OBJECTIVES A severe donor organ shortage leads to the death of a substantial number of patients who are listed for transplantation. The use of hearts from donors after circulatory death could significantly expand the donor organ pool, but due to ...
Bogdanova, Anna +5 more
core
Off-pump surgery for the poor ventricle? [PDF]
, 2018 Severely decreased ejection-fraction is an established risk-factor for worse outcome after cardiac surgery. We compare outcomes of off-pump coronary artery bypass grafting (OPCAB) and on-pump CABG (ONCABG) in patients with severely compromised EF.
Baulig, Werner +12 more
core
Comparative Study between Cardioplegic Solution (Custodiol) versus Conventional Cardioplegic Solutions in CABG Patients [PDF]
Benha Journal of Applied Sciences, 2021 Y.E. Risk +3 more
openaire +1 more source
Replacement of pulmonary artery trunk in sheep using tubular valved heterograft in non-aldehydic preservation [PDF]
, 2012 INTRODUCTION: The cardiac bioprostheses are related to thromboembolic events, infectious and degenerative diseases. Wear is mainly attributed to the denaturation of collagen. Glutaraldehyde, the predominant method of preservation of bioprostheses, favors
Almeida, Marco Antônio Cardoso de +7 more
core +3 more sources
Aortic stenosis and aortic regurgitation express different titin isoforms: Differences and relationships with functional and geometric characteristics [PDF]
, 2018 Background-Titin represents an important biomechanical sensor which determines compliance and diastolic/ systolic function of the left ventricle (LV). To assess the different titin-isoform expression and the relationships with functional and geometric ...
Antignano, Anita +5 more
core +1 more source
Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases [PDF]
, 2012 Aims: The human cardiac transient outward K + current Ito (encoded by Kv4.3 or KCND3) plays an important role in phase 1 rapid repolarization of cardiac action potentials in the heart.
Cheng, LC +8 more
core +1 more source