Results 81 to 90 of about 180,776 (249)

VSED Should Not Be a Pathway to MAiD (Though Both Are Ethically Permissible)

Bioethics, EarlyView.
ABSTRACT Recent changes in aid in dying laws have led some to argue for a pathway from Voluntarily Stopping Eating and Drinking (VSED) to Medical Aid in Dying (MAiD). Proponents point to the Sontag case as demonstrating the efficacy of the practice. This article first provides an overview of the development of the practice of VSED and MAiD and provides
D. B. Davison
wiley   +1 more source

The role of R-loops-mediated epigenetic regulation in genome stability maintenance and disease pathogenesis: a systematic review

Epigenetics
This systematic review synthesizes current evidence linking R-loops – associated processes with epigenetic regulation, genome stability, and human disease, integrating findings across DNA/RNA/protein modifications and 3D genome organization, and ...
Zi Hao Jiang, Di Feng Wang, Rui Shao, Xing Sheng Wang, Zi Ren Tang   +4 more
doaj   +1 more source

Comparison of chest compression quality in walking versus straddling cardiopulmonary resuscitation during stretcher transportation: A prospective randomised crossover study using manikins.

PLoS ONE, 2019
The optimal strategy to ensure chest compression quality for patients being transported on a stretcher has not been established yet. We hypothesised that straddling cardiopulmonary resuscitation may improve chest compression quality in patients being ...
Mikako Shinchi, Masanao Kobayashi, Kaori Soma, Akifumi Maeda   +3 more
doaj   +1 more source

Phase 3, randomised, placebo‐controlled trial of voxelotor for the resolution of leg ulcers in sickle cell disease: RESOLVE

British Journal of Haematology, EarlyView.
In this trial, conducted in Kenya, Nigeria and Brazil, the resolution of leg ulcers was similar between the voxelotor and placebo arms. In the 12‐week blinded period, the number of sickle cell anaemia with crisis events was higher in the voxelotor arm compared to placebo.
Bernhards Ogutu, Janet Oyieko, Halima Bello‐Manga, Adeseye Akinsete, Jessie Githanga, José Valber Lima Meneses, Carolyn Hoppe, Mark W. Davis, Jeremy Rupon, Ching‐Ray Yu, Roberto Pinto, Elena Tudone, Ibrahim Musa Idris, Martin Meremikwu, Aderson da Silva Araújo, Rodolfo D. Cançado, Guilherme Fonseca, Patrícia Santos Resende Cardoso, Obiageli Eunice Nnodu, on behalf of the RESOLVE Investigators   +19 more
wiley   +1 more source

Knowledge, Attitudes, and Stigmatizing Beliefs About HIV/AIDS Among Dental Students: The Impact of Clinical Education Level

European Journal of Dental Education, EarlyView.
ABSTRACT Background Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) remain major global public health concerns. Oral lesions are often among the earliest manifestations of HIV, placing dentists at the forefront of early detection and management.
Tuğba Aydoğdu, Berkant Sezer
wiley   +1 more source

Targeted temperature management alleviates post-resuscitation myocardial dysfunction by inhibiting ferroptosis

Cell Death Discovery
Targeted temperature management (TTM) is a vital intervention for cardiac arrest survivors to mitigate post-resuscitation myocardial dysfunction (PRMD). However, the optimal temperature for TTM remains a topic of debate.
Yingying Zhang, Weiwei Du, Ting Kong, Tianfeng Hua, Honghao Ma, Yan Hu, Sinong Pan, Bingrui Ling, Min Yang, Cheng Cheng   +9 more
doaj   +1 more source

Open-chest cardiopulmonary resuscitation versus closed-chest cardiopulmonary resuscitation in patients with cardiac arrest: a systematic review and meta-analysis

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2019
Background Cardiopulmonary resuscitation is the most urgent and critical step in the rescue of patients with cardiac arrest. However, only about 10% of patients with out-of-hospital cardiac arrest survive to discharge.
Mao Wang, Xiaoguang Lu, Ping Gong, Yilong Zhong, Dianbo Gong, Yi Song   +5 more
doaj   +1 more source

Dental Students' Perceived Confidence and Preparedness Following Medical Emergency Simulation Training in Australia

European Journal of Dental Education, EarlyView.
ABSTRACT Purpose/Objectives The study aimed to investigate dental students' perceived confidence and preparedness for managing medical emergencies within a dental setting. Methods Three‐hundred and six dental students completed a self‐administered questionnaire following a novel medical emergency simulation training. Descriptive analyses were conducted
Jessica Zachar, Sowmya Shetty
wiley   +1 more source

Machine learning models for predicting in-hospital mortality from acute pancreatitis in intensive care unit

BMC Medical Informatics and Decision Making
Background Acute pancreatitis (AP) represents a critical medical condition where timely and precise prediction of in-hospital mortality is crucial for guiding optimal clinical management. This study focuses on the development of advanced machine learning
Shuxing Wei, Hongmeng Dong, Weidong Yao, Ying Chen, Xiya Wang, Wenqing ji, Yongsheng Zhang, Shubin Guo   +7 more
doaj   +1 more source

Myeloid ACE2 protects against septic hypotension and vascular dysfunction through Ang-(1–7)-Mas-mediated macrophage polarization

Redox Biology
Angiotensin converting enzyme 2 (ACE2) is a new identified member of the renin-angiotensin-aldosterone system (RAAS) that cleaves angiotensin II (Ang II) to Ang (1–7), which exerts anti-inflammatory and antioxidative activities via binding with Mas ...
Jia-Xin Li, Xue Xiao, Fei Teng, Hui-Hua Li   +3 more
doaj   +1 more source