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Comparative Effectiveness of Ivabradine versus Digoxin in Patients with Heart Failure with Reduced Ejection Fraction and Chronic Kidney Disease: A Real-World Multicenter Cohort Study.

Cardiorenal Med
Wu JY, Lee KW, Huang SC, Chang HY, Lin YM.   +4 more
europepmc   +1 more source

Cardiac glycosides: Looking beyond heart failure and atrial fibrillation.

Indian J Pharmacol
Omole JG, Udom GJ, Aturamu A, Agbana RD, Aziakpono OM, Oritsemuelebi B, Bukke SPN, Okon IA, Yemitan OK.   +8 more
europepmc   +1 more source

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The therapeutic potential of novel cardiotonic agents

Expert Opinion on Investigational Drugs, 2003
During the course of treatment of heart failure patients, cardiotonic agents are inevitable for improvement of myocardial dysfunction. Clinically available agents, such as beta-adrenoceptor agonists and selective phosphodiesterase 3 inhibitors, act mainly via cyclic AMP/protein kinase A-mediated facilitation of Ca(2+) mobilisation (upstream mechanism).
Masao Endoh
exaly   +3 more sources

Quantitative structure - activity relationships of cardiotonic agents

2000
Quantitative structure-activity relationships (QSARs) of different cardiotonic agents are presented. A critical analysis of all QSARs provides a very vivid picture of the mechanisms of varying cardiotonic agents. The cardiotonics can be broadly put into 2 categories: cardiac glycosides and nonglycoside cardiotonics, which include phosphodiesterase of ...
Satya Prakash Gupta
exaly   +3 more sources

New cardiotonic agents: A search for digitalis substitute

Life Sciences, 1978
A E, Farah, A A, Alousi
exaly   +3 more sources

Cardiotonic agents and the sodium transient

Trends in Pharmacological Sciences, 1981
Abstract The authors discuss the possible link between membrane excitation and the calcium transient in cardiac muscle.
Tai Akera, Theodore M. Brody
openaire   +1 more source

Synthesis of Amrinone, A Cardiotonic Agent

Journal of the Chinese Chemical Society, 1988
AbstractA new synthesis of amrinone, 1, from 5‐(4‐pyridinyl) −2(1H)‐pyridone, 5, is reported. Nitration at C‐3 of the pyridone ring of 5 followed by reduction afforded amrinone. Another synthetic route was also carried out by bromination at C‐3 of the pyridone ring of 5 followed by substitution with sodium azide to give the corresponding azide ...
Min‐Jen Shiao, Puh Shieh, Jen‐Shiow Lai   +2 more
openaire   +1 more source

Synthesis of Milrinone, a Cardiotonic Agent

HETEROCYCLES, 1990
A new synthesis of milrinone from 6-methyl-5-(4-pyridinyl)-2(1H)-pyridone is reported. A convenient synthesis of 3,4'-bipyridines is achieved. They can be converted into pyridone by hydrogenolysis and hydrolysis, respectively.
Min-Jen Shiao, Li-Ming Shyu, Chieh-Fu Chen   +2 more
openaire   +1 more source

Mechanisms of Action of Novel Cardiotonic Agents

Journal of Cardiovascular Pharmacology, 2002
Regulation of myocardial contractility by cardiotonic agents is achieved by an increase in intracellular Ca2+ mobilization (upstream mechanism), an increase in Ca2+ binding affinity to troponin C (central mechanism), or facilitation of the process subsequent to Ca2+ binding to troponin C (downstream mechanism).
openaire   +2 more sources