Results 111 to 120 of about 5,916 (165)
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1984
Publisher Summary This chapter mainly discusses the major developments of new inotropic agents over the last three years. Compounds that are not reviewed are glucagon, anthopleurin,g ionophores, the cardiotonic principles of ginger, a newly synthesized analog of PGI2, and SKF 86466, a selective α2-adrenoceptor agonist.
Bernd Wetzel, Norbert Hauel
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Publisher Summary This chapter mainly discusses the major developments of new inotropic agents over the last three years. Compounds that are not reviewed are glucagon, anthopleurin,g ionophores, the cardiotonic principles of ginger, a newly synthesized analog of PGI2, and SKF 86466, a selective α2-adrenoceptor agonist.
Bernd Wetzel, Norbert Hauel
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Cardiovascular Pharmacology of the Vasodilator-Cardiotonic Agent, 349U85
Journal of Cardiovascular Pharmacology, 1992349U85 is a chemically novel, nonglycoside, noncatecholamine cardiotonic-vasodilator agent with a unique cardiovascular profile in vitro and in vivo. 349U85 and milrinone, 10(-6) to 3 x 10(-5) M each, produce concentration-dependent increases in tension development of 33-60% and 37-60%, respectively, with corresponding 5-18% and 17-55% increases in ...
R P, Steffen, W B, Wastila
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Cardiotonic agents in the management of chronic cardiac failure
American Heart Journal, 1982Heart failure is a syndrome with distinct clinical signs and symptoms. The severity of cardiac failure and a deterioration in functional capacity can be determined by a progressive exercise test and by the noninvasive determination of maximum oxygen uptake.
K T, Weber, V, Andrews, J S, Janicki
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European Journal of Pharmacology, 1987
The effect on the contractile protein system of MCI-154, a novel and potent cardiotonic agent, was examined by using thin bundles of chemically skinned fibers from the guinea-pig papillary muscles. MCI-154 increased the Ca2+ sensitivity of the contractile protein system of the cardiac skinned fibers.
Y, Kitada +3 more
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The effect on the contractile protein system of MCI-154, a novel and potent cardiotonic agent, was examined by using thin bundles of chemically skinned fibers from the guinea-pig papillary muscles. MCI-154 increased the Ca2+ sensitivity of the contractile protein system of the cardiac skinned fibers.
Y, Kitada +3 more
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Scaffold evaluation of liguzinediol analogs as novel cardiotonic agents
Die Pharmazie, 2013Liguzinediol (LZDO) could mediate the positive inotropic effects through sarcoplasmic reticulum Ca2+ ATPase-dependent mechanism without the risk of arrhythmia. However, the pharmacophore of LZDO contributed to the activities was not clear. The aim of this work was to explore the relationship between positive inotropic effect and scaffold of LZDO as ...
Liu, Z. +8 more
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Cardiovascular Properties of a New Cardiotonic Agent, MDL 19205
Journal of Cardiovascular Pharmacology, 1984The cardiovascular properties of a new cardiotonic agent, MDL 19205, were investigated in anesthetized and conscious dogs and in a dog heart-lung preparation. MDL 19205 (0.1-1 mg/kg), administered to anesthetized dogs by intravenous injection, produced a dose-related increase in cardiac contractile force lasting up to 1 h. It also produced a relatively
R C, Dage +3 more
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Cardiotonic Agent SCH00013 Prolongs Survival of Cardiomyopathic Hamsters
Journal of Cardiovascular Pharmacology, 2003The authors examined the effects of long-term treatment with SCH00013, a novel cardiotonic agent with calcium-sensitizing action, on survival of hereditary cardiomyopathic BIO 14.6 hamsters. Sixty-nine male hamsters at 223 days of age were divided into untreated, SCH00013-low (approximately 1 mg/kg/d), and SCH00013-high (approximately 10 mg/kg/d ...
Tadahito, Narita +4 more
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Analysis of the efficacy of the new cardiotonic agent TA-064
American Heart Journal, 1985TA-064 is a new cardiotonic agent which is also effective orally, according to investigations conducted in Japan. We analyzed computer-assisted alterations of pressure-volume relationships serially and of indirect myocardial oxygen consumption (MVO2) estimations on line during TA-064 influence in 16 patients with congestive cardiomyopathy: left ...
J, Thormann +5 more
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Annales de cardiologie et d'angeiologie, 1986
The possibilities for therapy in the field of severe cardiac insufficiency have been extended in recent years by the introduction of novel agents endowed with a positive inotropic action. These substances may be arranged in two large classes: sympathomimetic agents and "non sympathomimetic--non digitalis-like" inotropic agents.
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The possibilities for therapy in the field of severe cardiac insufficiency have been extended in recent years by the introduction of novel agents endowed with a positive inotropic action. These substances may be arranged in two large classes: sympathomimetic agents and "non sympathomimetic--non digitalis-like" inotropic agents.
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Calcium Signaling and Pharmacology of Cardiotonic Agents
1995The mechanisms of action of drugs that act on myocardial contractility through different signal transduction pathways have lately been elucidated to a great extent, in particular since the introduction of novel methods for detecting changes in the intracellular concentration of Ca++ ions, ([Ca++] i), by the application of aequorin, quin-2, fura-2 and ...
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