Results 231 to 240 of about 55,383 (254)
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Scaffold evaluation of liguzinediol analogs as novel cardiotonic agents.
Die Pharmazie, 2013Liguzinediol (LZDO) could mediate the positive inotropic effects through sarcoplasmic reticulum Ca2+ ATPase-dependent mechanism without the risk of arrhythmia. However, the pharmacophore of LZDO contributed to the activities was not clear. The aim of this work was to explore the relationship between positive inotropic effect and scaffold of LZDO as ...
Hongmei Wen +8 more
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Use of Cardiotonic Agent (Mephentermine) in Myocardial Depression Due to Potassium
Archives of Surgery, 1959Recent studies have demonstrated that prolonged induced cardiac arrest is followed by myocardial damage 1,2 and depressed ventricular function 3 in the dog. It has also been shown that this depression may be limited by prophylactic digitalization 4 and by hypothermia.
Willman Vl +3 more
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Pharmacology of RG W-2938: A Cardiotonic Agent with Vasodilator Activity
Journal of Cardiovascular Pharmacology, 1990The cardiovascular effects of RG W-2938, 6-[6-(3,4-dihydro-3-methyl-2(1H)-2-oxoquinazolinyl)]-4,5-dihydro-3 (2H-pyridazinone, a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent were examined in vivo in anesthetized and conscious dogs and in vitro in isolated guinea pig hearts; in the latter, RG W-2938 5 nmol-5 mumol increased ...
William C. Faith +6 more
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Metabolism of denopamine, a new cardiotonic agent, in the rat and dog.
Drug Metabolism and Disposition, 1985The metabolism of denopamine, (R)-(-)-1-(p-hydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino] ethanol, a new, orally active, selectively inotropic cardiotonic agent, was studied in the rat and dog. Animals were given single oral doses of 5 mg/kg of denopamine labeled with 14C.
S, Furuuchi +3 more
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Cardiovascular Actions of DPI 201–106, a Novel Cardiotonic Agent
Journal of Cardiovascular Pharmacology, 1986DPI 201-106 (4-[3-(4-diphenylmethyl-1-piperazinyl)-2-hydroxypropoxy]-1H-indole -2- carbonitrile) is characterized by a marked cardiotonic activity. The compound exerted positive inotropic effects in anesthetized and conscious dogs, pithed open-chest cats, and isolated hearts of cardiomyopathic hamsters and vanadate-treated guinea-pig atria.
G Scholtysik +3 more
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Quantitative structure - activity relationships of cardiotonic agents
2000Quantitative structure-activity relationships (QSARs) of different cardiotonic agents are presented. A critical analysis of all QSARs provides a very vivid picture of the mechanisms of varying cardiotonic agents. The cardiotonics can be broadly put into 2 categories: cardiac glycosides and nonglycoside cardiotonics, which include phosphodiesterase of ...
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Pharmacology of LY175326: a potent cardiotonic agent with vasodilator activities.
The Journal of Pharmacology and Experimental Therapeutics, 1985Compound LY175326 is one of a series of novel cardiovascular agents with both inotropic and vasodilator activities. In cat papillary muscles, LY175326 increased contractility in a concentration-dependent manner; these actions were not blocked by prazosin, propranolol or cimetidine.
J S, Hayes +4 more
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Pharmacological Actions of DPN 205–734, a Novel Cardiotonic Agent
Journal of Cardiovascular Pharmacology, 1988DPN 205-734 [5-(4-cyanophenyl)-1,2-dihydro-6-methyl-2-oxopyridin-3-carbo nitrile] was investigated in vitro in Langendorff rabbit hearts, guinea pig and rabbit papillary muscles, and rat myocardium and in vivo in anesthetized and unanesthetized dogs, pithed open-chest cats, anesthetized rats, and cardiomyopathic hamsters.
R. Salzmann +3 more
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Mechanism of the Vasodilator Effects of the Cardiotonic Agent DPI 201-106
Journal of Cardiovascular Pharmacology, 1985DPI 201-106 (DP) is a new cardiotonic agent. In experiment on cats anaesthetized with chloralose/urethane, it lowered blood pressure and caused peripheral vasodilatation at doses between 0.3 and 3 mg/kg, infused i.v. Furthermore, DPI lowered heart rate and increased coronary blood flow (measured with tracer microspheres).
Akiko Hof, Robert P. Hof
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Chapter 10. Cardiotonic Agents for the Treatment of Heart Failure
1981Publisher Summary Effective pharmacologic therapy of heart failure is brought about either by enhancing the contractile state of the failing pump with positive inotropic agents or by the adjustment of the peripheral circulatory state with peripheral vasodilators. The applications of agents that stimulate myocardial contractility are of major value in
J. A. Bristol, Dale B. Evans
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