Results 91 to 100 of about 5,087,575 (343)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Effect of supplementation with probiotics or synbiotics on cardiovascular risk factors in patients with metabolic syndrome: a systematic review and meta-analysis of randomized clinical trials

Frontiers in Endocrinology
PurposeThe effectiveness of probiotics or synbiotics in adults with metabolic syndromes (MetS) remains controversial, this meta-analysis will further analyze the effects of probiotics or synbiotics on cardiovascular factors in adults with MetS.MethodsWe ...
TingRui Chen, Jing Wang, ZeKun Liu, Fei Gao   +3 more
doaj   +1 more source

Prehypertension and its correlation with cardiovascular risk factors – A study among health sciences students in Malaysia

Journal of Integrated Health Sciences, 2013
Introduction: The levels of blood pressure (BP) are important as it is a potential risk factor that predisposes towards cardiovascular disease (CVD) when the levels are high.
Mohit Shahi, Chow W Li
doaj   +1 more source

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Prevalent Atherosclerotic Cardiovascular Disease Among Veterans by Sexual Orientation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Seven million lesbian, gay, and bisexual (LGB) adults will be aged >50 years by 2030; assessing and addressing their risk for cardiovascular disease is critical.
Carl G. Streed, Meredith S. Duncan, Kory R. Heier, T. Elizabeth Workman, Lauren B. Beach, Billy A. Caceres, John R. O'Leary, Melissa Skanderson, Joseph L. Goulet   +8 more
doaj   +1 more source

COPD and cardiovascular disease [PDF]

, 2018
COPD is one of the major public health problems in people aged 40 years or above. It is currently the 4th leading cause of death in the world and projected to be the 3rd leading cause of death by 2020.
André, S, Areias, V, Boléo-Tomé, JP, Cardoso, J, Conde, B, Fragoso, E, GI DPOC-Grupo de Interesse na Doença Pulmonar Obstrutiva Crónica   +6 more
core   +4 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Cardiovascular diseases, risk factors and barriers in their prevention in Croatia [Kardiovaskularne bolesti, rizični faktori i zapreke za prevenciju u Hrvatskoj] [PDF]

, 2009
Cardiovascular diseases are the leading cause of death in Croatia, with significant regional differences. Despite high mortality rates, high prevalence of various cardiovascular risk factors and well organized public health network, comprehensive system ...
Andrić, Adriana, Džakula, Aleksandar, Juriša, Adriana, Polašek, Ozren, Radaković, Nikolina, Todorović, Goran, Šogorić, Selma   +6 more
core  

Walks4work: Rationale and study design to investigate walking at lunchtime in the workplace setting [PDF]

, 2012
Background: Following recruitment of a private sector company, an 8week lunchtime walking intervention was implemented to examine the effect of the intervention on modifiable cardiovascular disease risk factors, and further to see if walking environment ...
A Alwan, A Puig-Ribera, AJ Hautala, AJ Minisi, AJ Nelson, BJ Park, C Tudor-Locke, CB Chan, CL Craig, CR Cole, CR Cole, D Watson, Daniel K Brown, Department of Health, Department_of_Health, DP Zipes, DR Seals, EK Nisbet, EM Murtagh, EO Nishime, G Borg, GE Billman, GE Duncan, GJ Welk, GR Sandercock, H Hemingway, H Tsuji, HE Brown, I Hess, J Barton, J Barton, J Pretty, J Pretty, J Pretty, J Stevens, Jo L Barton, JP Buckley, Jules Pretty, K Sykes, KY Chen, LW Rystedt, M Rosenberg, MH Murphy, MS Penn, MT La Rovere, MT La Rovere, N Gilson, NA King, Q Li, R Rosmond, RP Juster, RW Hoyt, S Cohen, S Ogoh, SB Racette, SN Blair, T Chandola, T Cox, T Hartig, Task Force, Valerie F Gladwell, VF Gladwell, VS Conn, WB Schaufeli, WB Schaufeli, WHO, WHO, WHO, WL Haskell, X Jouven   +69 more
core   +2 more sources