Results 81 to 90 of about 2,900,397 (306)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Phenomenology study: the nurse perception of experience in providing spiritual nursing care in the cardiovascular unit

Healthcare in Low-resource Settings
Nurses who provide nursing care are urgently required to assess the patient’s spiritual needs so a correct nursing intervention can be given to the patient.
Safri Safri, Elly Nurachmah, Budhi Setianto, Jahja Umar, Sri Yona   +4 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Association Between Thymosin β4 and Coronary Arterial Lesions in Children with Kawasaki Disease

Journal of Inflammation Research
Jinhui Wu, Penghui Yang, Jing Zhang, Zhuo Chen, Yi Wei, Ya Su, Qijian Yi Department of Cardiovascular Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory ...
Wu J, Yang P, Zhang J, Chen Z, Wei Y, Su Y, Yi Q   +6 more
doaj  

The examination of physical function and cognitive outcomes in middle-to-older high-risk adults: an unsupervised clustering method

Frontiers in Public Health
Alzheimer’s disease rates are expected to triple by 2050. Early detection and specific mitigation efforts are warranted to blunt the alarming increase.
Joshua L. Gills, Joshua L. Gills, Megan D. Jones, Anthony Campitelli, Anthony Campitelli, Sally Paulson, Sally Paulson, Cody Diehl, Charles Rodgers, Charles Rodgers, Erica Madero, Jennifer R. Myers, Kelsey Bryk, Omonigho Michael Bubu, Omonigho Michael Bubu, Omonigho Michael Bubu, Jordan M. Glenn, Michelle Gray   +17 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Triglyceride-Glucose Index and Neutrophil-to-Lymphocyte Ratio: A Metabolic-Inflammatory Signature for Mortality Prediction in a Multicenter Retrospective Cohort of 1249 Dialysis Patients with Coronary Artery Disease

Journal of Inflammation Research
Yike Li,1,* Peng Li,2,* Qiang Tang,3,* Ting Jiao,4 Yanxiang Gao,5 Shuoyan An,5 Hao Jiang,3 Hui Cheng,6 Zixuan Yang,1 Jiahui Zhou,1 Yuxuan Sun,7 Yining Yang,6 Jingang Zheng1,5 1Department of Cardiology, China-Japan Friendship ...
Li Y, Li P, Tang Q, Jiao T, Gao Y, An S, Jiang H, Cheng H, Yang Z, Zhou J, Sun Y, Yang Y, Zheng J   +12 more
doaj  

Heart Rate, Blood Pressure, Rate Pressure Product in Young Healthy Females at Three Time Points of Menstrual Cycle: Associations with Cycle Length and Body Weight

Journal of Clinical and Diagnostic Research
Introduction: The menstrual cycle exerts profound cyclical effects on the functioning of the reproductive and cardiovascular systems in health and disease. Cyclical changes in the cardiovascular system due to the menstrual cycle are less studied compared
Hemalatha Manjeshwara, V Suganthi, Amudharaj Dharmalingam, Milind V Bhutkar, Gopinath Manavazhagan   +4 more
doaj   +1 more source

Comparative cost-effectiveness analyses of cardiovascular magnetic resonance and coronary angiography combined with fractional flow reserve for the diagnosis of coronary artery disease. [PDF]

, 2014
According to recent guidelines, patients with coronary artery disease (CAD) should undergo revascularization if significant myocardial ischemia is present.
Pilz, G., Steffen E Petersen, Pilz, G, Petersen, SE, Wasserfallen, J-B, Guenter Pilz, Petersen, S.E., Favre, David, Petersen, Steffen E., Anja Wagner, Schwitter, J.J., Pinget, C, Favre, D., Wagner, A, Wagner, A., Jean-Blaise Wasserfallen, Karine Moschetti, Moschetti, K., Moschetti, Karine, Wasserfallen, JB, Schwitter, J, Schwitter, Juerg, Wasserfallen, Jean-Blaise, David Favre, Schwitter, JJ, Christophe Pinget, Pinget, Christophe, Wasserfallen, J.B., Pilz, Guenter, Pinget, C., Wagner, Anja, Juerg J Schwitter, Moschetti, K, Favre, D   +33 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source