Results 71 to 80 of about 5,262,545 (393)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Rates of Infections, Malignancies, Cardiovascular Outcomes, and Death in Individuals with Hospital-treated Alopecia Areata: A Registry-based Cohort Study in Denmark

Acta Dermato-Venereologica
The emergence of new systemic treatments for alopecia areata underscores the importance of estimating rates of potential treatment safety events among individuals with alopecia areata.
Sissel Brandt Toft Sørensen, Prethibha George, Oladayo Jagun, Robert Wolk, Lynne Napatalung, Samuel H. Zwillich, Lars Iversen, Vera Ehrenstein   +7 more
doaj   +1 more source

Effects of dalcetrapib in patients with a recent acute coronary syndrome [PDF]

, 2012
In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events.
Abt, Markus, Ballantyne, Christie M., Barter, Philip J., Brumm, Jochen, Chaitman, Bernard R., Colquhoun, David, Holme, Ingar M., Kallend, David, Leiter, Lawrence A., Leitersdorf, Eran, McMurray, John J. V., Mundl, Hardi, Nicholls, Stephen J., Olsson, Anders G., Schwartz, Gregory G., Shah, Prediman K., Tardif, Jean-Claude, The dal-OUTCOMES Investigators, Wright, R. Scott   +18 more
core   +2 more sources

Cardiovascular Metabolomics [PDF]

Circulation Research, 2018
Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states.
Robert W, McGarrah, Scott B, Crown, Guo-Fang, Zhang, Svati H, Shah, Christopher B, Newgard   +4 more
openaire   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

The Impact of Endurance Running Training on the Lipid Profile in Professional and Amateur Athletes: A Comprehensive Review

Quality in Sport
Endurance running is one of the most popular forms of physical activity, influencing many aspects of health, including lipid metabolism. Regular endurance exercise positively affects the lipid profile, which plays a key role in preventing cardiovascular ...
Adam Zarzycki, Dominika Nowak, Magdalena Próchnicka, Michał Siwek, Jakub Hamouta, Patrycja Długosz, Julia Konat, Wiktor Doroszuk, Jan Noskowicz, Jan Urban   +9 more
doaj   +1 more source

Cultural challenges to secondary prevention: Implications for Saudi women [PDF]

, 2012
Like other highly developed countries, cardiovascular disease (CVD) and coronary heart disease (CHD) are major health problems in Saudi Arabia. The aetiology of cardiovascular disease (CVD) burden within the Saudi population is similar to Western ...
Clark, Robyn, Rawas, Hawazen, Windsor, Carol, Yates, Patsy   +3 more
core   +2 more sources

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

New England Journal of Medicine, 2018
Background Patients who have had an acute coronary syndrome are at high risk for recurrent ischemic cardiovascular events. We sought to determine whether alirocumab, a human monoclonal antibody to proprotein convertase subtilisin–kexin type 9 (PCSK9 ...
G. Schwartz, G. Steg, M. Szarek, Deepak Bhatt, Vera A. Bittner, R. Diaz, Jay M. Edelberg, Shaun G Goodman, C. Hanotin, Robert A Harrington, W. Jukema, G. Lecorps, K. Mahaffey, A. Moryusef, R. Pordy, K. Quintero, Matthew T. Roe, W. Sasiela, J. Tamby, P. Tricoci, Harvey D. White, Andreas M. Zeiher   +21 more
semanticscholar   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Are Large Physiological Reactions to Acute Psychological Stress Always Bad for Health? [PDF]

, 2009
How we react physiologically to stress has long been considered to have implications for our health. There is now persuasive evidence that individuals who show large cardiovascular reactions to stress are at increased risk of developing cardiovascular ...
Acheson, Adolphs, Allen, Al’Absi, Al’Absi, Al’Absi, Anisman, Bachen, Barch, Barnett, Bechara, Beck, Blair, Bosch, Bosch, Bosch, Brydon, Buchanan, Cacioppo, Caldji, Carney, Carroll, Carroll, Carroll, Carroll, Carroll, Carroll, Carroll, Carroll, Caspi, Critchley, Cuthbert, Damasio, Damasio, De Boer, De Boer, Dhabhar, Dhabhar, Ditto, Drummond, Edwards, Edwards, Edwards, Edwards, Enoch, Everson, Everson, Fredrikson, Gagnon, Georgiades, Gianaros, Gianaros, Girdler, Glahn, Goldman, Grassi, Hemingway, Idler, Ishiguro, Kanitz, Kapuku, Kario, Kario, Kibler, Kirschbaum, Kirschbaum, Kirschbaum, Krantz, Lazarus, Leor, Lesch, Light, Lipsky, Liu, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lovallo, Lowe, Lynch, Maier, Manuck, Manuck, Manuck, Manuck, Markovitz, Matthews, Matthews, Meaney, Meaney, Meisel, Mesulam, Millan, Miller, Mischler, Moss, Muldoon, Murdison, Naqvi, Newman, Obrist, Panknin, Patterson, Patterson, Phillips, Phillips, Phillips, Phillips, Phillips, Plotsky, Pomerleau, Rohleder, Rolls, Roy, Schwartz, Sheffield, Silberman, Sims, Smith, Smolka, Sorocco, Straneva, Tentolouris, Tentolouris, Tofler, Treiber, Treiber, Trichopoulos, Tuchscherer, Turner, Ungerleider, Vandenbergh, Welle, Williams, Williams, Witte, Wulsin, York, Zgraggen, Zigmond, Zubieta   +144 more
core   +2 more sources