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Cardiovascular effects of immunosuppression agents
Frontiers in Cardiovascular Medicine, 2022 Immunosuppressive medications are widely used to treat patients with neoplasms, autoimmune conditions and solid organ transplants. Key drug classes, namely calcineurin inhibitors, mammalian target of rapamycin (mTOR) inhibitors, and purine synthesis inhibitors, have direct effects on the structure and function of the heart and vascular system.
Aly Elezaby +4 more
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Cardiovascular Management in Pregnancy [PDF]
Circulation, 2015 Thrombotic complications of pregnancy are a major cause of morbidity and mortality to the mother and fetus. Pulmonary embolism is a leading cause of maternal death and accounts for 10.3% of all maternal deaths in the United States.1,2 Overall, pregnancy increases the risk of venous thromboembolism (VTE) 5-fold, with an additional increase in risk in ...
Anne Marie Valente +2 more
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Vascular complications of cancer chemotherapy [PDF]
, 2015 Development of new anticancer drugs has resulted in improved mortality rates and 5-year survival rates in patients with cancer. However, many of the modern chemotherapies are associated with cardiovascular toxicities that increase cardiovascular risk in ...
Cameron, Alan C. +2 more
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Exosomes as agents of change in the cardiovascular system [PDF]
Journal of Molecular and Cellular Cardiology, 2017 Exosomes have an evolving role in paracrine and autocrine signaling, which is enhanced because these lipid vesicles are quite stable and can deliver miRNA, DNA, protein and other molecules to cells throughout the body. Most cell types release exosomes, and exosomes are found in all biological fluids, making them accessible biomarkers.
A.J. Poe, A.A. Knowlton
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The role of urate and xanthine oxidase in vascular oxidative stress:Future directions [PDF]
, 2009 Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high.
George, Jacob, Struthers, Allan
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Infectious agents in atherosclerotic cardiovascular diseases through oxidative stress [PDF]
, 2017 Accumulating evidence demonstrates that vascular oxidative stress is a critical feature of atherosclerotic process, potentially triggered by several infectious agents that are considered as risk co-factors for the atherosclerotic cardiovascular diseases (
Di Pietro, M +4 more
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Acute poisoning by cardiovascular agents
Vojnosanitetski pregled, 2003 In order to determine the frequency, severity of poisoning, and the efficacy of the applied therapeutic measures, retrospective study of 391 patients treated for acute drug poisoning was performed during one-year period at the Clinic for Emergency and Clinical Toxicology and Pharmacology.
Dušan Jovanović +5 more
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Targeting acute hyperglycaemia in clinical practice [PDF]
, 2007 The UKPDS established the benefit of tight glycaemic control in preventing microvascular disease but was unable to demonstrate an effect on cardiovascular disease.
Heller, S.
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Pharmacology of cardiovascular chronotherapeutic agents [PDF]
American Journal of Hypertension, 2001 Although sudden cardiac death, myocardial infarction, or stroke can occur at any time of day, event rates increase during the waking hours, particularly in the morning. In most people-both normotensive and hypertensive-blood pressure (BP) rises rapidly in the early morning hours, the time when most individuals wake and begin their day.
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Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms [PDF]
, 2018 Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
Guzik, Tomasz J. +2 more
core +1 more source