Results 71 to 80 of about 4,518,294 (325)

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source

Editor's Pick: Protecting The Heart in Cancer Patients: The Role of Cardio-Oncology

European Medical Journal Cardiology, 2017
Cardiac disease often impacts cancer therapy, from direct toxicity of cancer therapeutic agents to the coronary endothelium, the myocardium, heart valves, and other structures.
Ronald J. Krone
doaj  

Evaluation of the HbA1c Reduction Cut Point for a Nonglycemic Effect on Cardiovascular Benefit of Hypoglycemic Agents in Patients with Type 2 Diabetes Based on Endpoint Events

International Journal of Endocrinology, 2018
Background. Atherosclerotic cardiovascular disease (ASCVD) is a major cause of death among patients with diabetes but can be improved by certain hypoglycemic agents.
Yuchao Wu, Lizhi Tang, Fang Zhang, Zhe Yan, Jing Li, Nanwei Tong   +5 more
doaj   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source

Separate and Unequal: Cardiovascular Medicine in Black Americans

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Neal K. Lakdawala
doaj   +1 more source

Use of Cardiovascular Drugs for Primary and Secondary Prevention of Cardiovascular Disease Among Rural-Dwelling Older Chinese Adults

Frontiers in Pharmacology, 2020
Cardiovascular risk factors and related disorders are common among older adults, and use of various classes of cardiovascular (CV) drugs could reduce the risk of cardiovascular disease (CVD).
Lin Cong, Lin Cong, Lin Cong, Yifei Ren, Tingting Hou, Tingting Hou, Tingting Hou, Xiaolei Han, Yi Dong, Yongxiang Wang, Yongxiang Wang, Yongxiang Wang, Qinghua Zhang, Qinghua Zhang, Qinghua Zhang, Rui Liu, Shan Xu, Lidan Wang, Yifeng Du, Yifeng Du, Yifeng Du, Chengxuan Qiu, Chengxuan Qiu   +22 more
doaj   +1 more source

Key Trends and Insights in Smart Polymeric Skin Wearable Patches

Advanced Engineering Materials, EarlyView.
Intelligent polymers, which respond to various physical and biological stimuli, are explored for the development of skin wearable patches in biomedical applications. Smart polymers, also known as intelligent or stimuli‐responsive polymers, play a crucial role in the development of advanced wearable patches due to their versatility and softness.
Sergio J. Peñas‐Núñez, Rajat Rai, Miryam Criado‐Gonzalez   +2 more
wiley   +1 more source

Diabetes: the place of new therapies

Therapeutic Advances in Endocrinology and Metabolism, 2019
Until the discovery of insulin in 1921 there were no effective treatments for diabetes mellitus. After the advent of long-acting insulin, the first oral agents, sulfonylureas became available in the mid-1950s, quickly followed (outside of the United ...
Ketan Dhatariya
doaj   +1 more source

Cardiovascular safety of osteoanabolic agents

Journal of Bone and Mineral Metabolism
Abstract Purpose Several osteoanabolic agents have been developed to build new bone more efficiently than anti-resorptive drugs. Among them, romosozumab, an anti-sclerostin antibody, is a potent pharmacological tool to prevent fractures in osteoporosis patients.
openaire   +2 more sources

Cardiovascular Profile of the Antihypertensive Agent, Guanadrel

Experimental Biology and Medicine, 1972
SummaryGuanadrel was evaluated for its cardiovascular profile and was found to possess properties which are desirable in the treatment of hypertension. The compound causes blockade of the sympathetic nerve ending and depletion of peripheral and “hypothalamic” catecholamines.
J. Hidalgo, T. P. Pruss
openaire   +3 more sources