Results 71 to 80 of about 742,288 (358)

Rhizoma Coptidis: A Potential Cardiovascular Protective Agent [PDF]

open access: yesFrontiers in Pharmacology, 2016
أمراض القلب والأوعية الدموية (CVDs) هي من بين الأسباب الرئيسية للاعتلال والوفيات في كل من العالم المتقدم والنامي. Rhizoma coptidis (RC)، المعروف باسم Huang Lian في الصين، هو الجذمور المجفف للنباتات الطبية من عائلة Ranunculaceae، مثل Coptis chinensis Franch و C. deltoidea C.Y. Cheng et Hsiao و C. teeta wall الذي استخدمه الأطباء الطبيون الصينيون لأكثر من
Hui-Li Tan   +12 more
openaire   +3 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu   +9 more
wiley   +1 more source

Evaluation of the HbA1c Reduction Cut Point for a Nonglycemic Effect on Cardiovascular Benefit of Hypoglycemic Agents in Patients with Type 2 Diabetes Based on Endpoint Events

open access: yesInternational Journal of Endocrinology, 2018
Background. Atherosclerotic cardiovascular disease (ASCVD) is a major cause of death among patients with diabetes but can be improved by certain hypoglycemic agents.
Yuchao Wu   +5 more
doaj   +1 more source

Effects of vildagliptin on ventricular function in patients with type 2 diabetes mellitus and heart failure: a randomized placebo-controlled trial [PDF]

open access: yes, 2017
Objectives: This study sought to examine the safety of the dipeptidyl peptidase-4 inhibitor, vildagliptin, in patients with heart failure and reduced ejection fraction.
Bolli, Geremia B.   +7 more
core   +2 more sources

Novel Antiplatelet Agents in Cardiovascular Disease

open access: yesJournal of Cardiovascular Pharmacology and Therapeutics, 2020
Antiplatelet therapy reduces atherothrombotic risk and has therefore become a cornerstone in the treatment of cardiovascular disease. Aspirin, adenosine diphosphate P2Y12 receptor antagonists, glycoprotein IIb/IIIa inhibitors, and the thrombin receptor blocker vorapaxar are effective antiplatelet agents but significantly increase the risk of bleeding.
Maximilian Tscharre   +2 more
openaire   +2 more sources

Cardiovascular Management in Pregnancy [PDF]

open access: yesCirculation, 2015
Thrombotic complications of pregnancy are a major cause of morbidity and mortality to the mother and fetus. Pulmonary embolism is a leading cause of maternal death and accounts for 10.3% of all maternal deaths in the United States.1,2 Overall, pregnancy increases the risk of venous thromboembolism (VTE) 5-fold, with an additional increase in risk in ...
Christina D, Yarrington   +2 more
openaire   +2 more sources

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund   +3 more
wiley   +1 more source

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide [PDF]

open access: yes, 2001
Background: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial KATP channel opening in myocytes. Glimepiride (Glim) is a new sulfonylurea reported to affect
Baxter, G.F.   +5 more
core  

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